@misc{10481/64324,
year = {2020},
month = {4},
url = {http://hdl.handle.net/10481/64324},
abstract = {Chromophore-appended cyclodextrins combine the supramolecular loading capabilities of cyclodextrins
(CDs) with the optical properties of the affixed chromophores. Among fluorescent materials, carbon dots
(CNDs) are attractive and the feasibility of CND-appended CDs as sensors has been demonstrated by
different authors. However, CNDs are intrinsically heterogeneous materials and their ulterior functionalization
yields hybrid composites that are not well defined in terms of structure and composition. Inspired
by the fluorescence properties of 5-oxo-1,2,3,5-tetrahydroimidazo[1,2-a]pyridine-7-carboxylic acid
(IPCA), the most paradigmatic of the molecular fluorophores detected in CNDs, herein we report two
highly efficient synthetic chemical strategies for the preparation of IPCA-appended CDs that behave as
CND-based CD “turn off–on” biosensors suitable for the analysis of cholesterol and β-galactosidase
activity. We have deconstructed the CND–CD systems to demonstrate that (i) the role of CNDs is limited
to acting as a support for the molecular fluorophores produced during their synthesis and (ii) the molecular
fluorophores suffice for the determination of the enzymatic activity based on the quenching by
p-nitrophenol as a sacrificial quencher.},
organization = {Ministerio de Economía, Industria y Competitividad, Spain 	
CTQ2017-86125-P
CTQ2016-78754-C2-1-R},
publisher = {Royal Society Chemistry},
title = {Carbon dots-inspired fluorescent cyclodextrins: competitive supramolecular “off–on” (bio)sensors},
doi = {10.1039/d0nr01004a},
author = {De los Reyes Berbel, Eduardo and Ortiz Gómez, Inmaculada and Ortega Muñoz, Mariano and Salinas Castillo, Alfonso and Capitán Vallvey, Luis Fermín and Hernández Mateo, Fernando and López Jaramillo, Francisco Javier and Santoyo González, Francisco},
}