@misc{10481/64285,
year = {2020},
month = {4},
url = {http://hdl.handle.net/10481/64285},
abstract = {Introduction: Melatonin is a hormone used in the treatment of diverse pathologies
due to its ability to regulate numerous physiological processes
related to biological rhythms and neuroendocrine function.
Material and methods: This study examines whether or not the antioxidant
capacities of melatonin are modified during the creation of fast disintegrating
oral tablets (FDDTs) through direct compression in which different
concentrations of the active substance (3, 5, 10 and 60 mg) and excipients
are made. In addition, the antioxidant capacity of melatonin is compared
with that of reference antioxidants such as vitamin C, Trolox, resveratrol,
glutathione and nicotinamide adenine dinucleotide phosphate (NADPH).
Results: Melatonin has a lower antioxidant capacity only 5% of the capacity
of resveratrol. Resveratrol is the compound having the greatest antioxidant
capacity. As for the influence of the tablets components, it was found
that only at higher concentrations of melatonin (60 mg/tablet), with the
excipients mannitol, polyvinylpyrrolidone (crospovidone), magnesium stearate
and anhydrous colloidal silica, did a decrease occur in the antioxidant
capacity value, possibly due to the lower percentage of these excipients in
the formulation.},
publisher = {Termedia Publishing House LTD},
keywords = {Melatonin},
keywords = {Antioxidants},
keywords = {Total antioxidative capacity},
keywords = {Ferric ion reducing antioxidant power},
keywords = {Fast dissolving/disintegrating tablets},
title = {Contribution to determining the antioxidant capacity of melatonin in orodispersible tablets – comparison with reference antioxidants},
doi = {10.5114/aoms.2020.94106},
author = {Muñoz, Herminia and García, Sergio and Ruiz Martínez, Adolfina},
}