@misc{10481/64279,
year = {2020},
url = {http://hdl.handle.net/10481/64279},
abstract = {The widespread use of perfluoroalkyl substances (PFAS) is resulting in a broad human exposure to these
endocrine disrupting chemicals (EDCs), prompting biomonitoring research to evaluate its magnitude and impact,
especially during critical windows of exposure such as fetal and perinatal periods. This study was focused on
developing a method to determine 10 PFAS in placental tissue by combining salt-assisted liquid-liquid extraction
with dispersive liquid-liquid microextraction and using liquid chromatography-tandem mass spectrometry.
Chemometric strategies were applied to optimize the experimental parameters. The limit of quantification was
0.02 ng g− 1 for all analytes, and the inter-day variability (as relative standard deviation) ranged from 7.9% to
13.8%. Recoveries ranged from 88.2% to 113.9%. The suitableness of the procedure was demonstrated by
assessing the targeted compounds in 20 placenta samples. The highest concentrations were recorded for perfluorooctanoic acid and perfluorooctane sulfonate, with maximum concentrations of 0.62 and 1.02 ng g− 1 and
median concentrations of 0.13 and 0.53 ng g− 1
, respectively. Median concentrations of the other PFAS ranged
from detected values to 0.08 ng g− 1
. This analytical procedure yields useful data on fetal exposure to PFAS.},
organization = {European Union's Horizon 2020 research and innovation programme 	
733032},
organization = {Instituto de Salud Carlos III

FIS-PI16/01820
FIS-PI16/01812
FIS-PI16/01858},
organization = {Instituto de Salud Carlos III},
organization = {"Fondo Europeo de Desarrollo Regional" (ISCIII/FEDER) 	
CD17/00212},
publisher = {ELSEVIER},
keywords = {Perfluoroalkyl substances},
keywords = {Placenta},
keywords = {Dispersive liquid-liquid microextraction},
keywords = {LC–MS/MS},
keywords = {HBM4EU},
title = {Assessment of perfluoroalkyl substances in placenta by coupling salt assisted liquid-liquid extraction with dispersive liquid-liquid microextraction prior to liquid chromatography-tandem mass spectrometry},
doi = {10.1016/j.talanta.2020.121577},
author = {Vela Soria, Fernando and Mustieles Miralles, Vicente and Fernández Cabrera, Mariana Fátima},
}