@misc{10481/64258,
year = {2020},
url = {http://hdl.handle.net/10481/64258},
abstract = {Recent studies have shown that maternal supplementation with folate and long-chain
polyunsaturated fatty acids (LC-PUFAs) during pregnancy may affect children’s brain development.
We aimed at examining the potential long-term effect of maternal supplementation with fish oil
(FO) and/or 5-methyl-tetrahydrofolate (5-MTHF) on the brain functionality of offspring at the age
of 9.5–10 years. The current study was conducted as a follow-up of the Spanish participants
belonging to the Nutraceuticals for a Healthier Life (NUHEAL) project; 57 children were divided
into groups according to mother’s supplementation and assessed through functional magnetic
resonance imaging (fMRI) scanning and neurodevelopment testing. Independent component analysis
and double regression methods were implemented to investigate plausible associations. Children
born to mothers supplemented with FO (FO and FO + 5-MTHF groups, n = 33) showed weaker
functional connectivity in the default mode (DM) (angular gyrus), the sensorimotor (SM) (motor and
somatosensory cortices) and the fronto-parietal (FP) (angular gyrus) networks compared to the No-FO
group (placebo and 5-MTHF groups, n = 24) (PFWE < 0.05). Furthermore, no differences were found
regarding the neuropsychological tests, except for a trend of better results in an object recall (memory)
test. Considering the No-FO group, the aforementioned networks were associated negatively with
attention and speed-processing functions. Mother’s FO supplementation during pregnancy seems
to be able to shape resting-state network functioning in their children at school age and appears to
produce long-term effects on children´s cognitive processing.},
organization = {European Union (EU)

212652
007036},
organization = {Commission of the European Community within the 5th Framework Program 	
QLK1-CT-1999-00888},
organization = {European Research Council (ERC)

322605 META-GROWTH},
organization = {Spanish Ministry of Science, Innovation and Universities 	
FJCI-2017-33396},
publisher = {MDPI},
keywords = {Fish oils},
keywords = {Folate},
keywords = {Pregnancy},
keywords = {Brain Function},
keywords = {Resting-state functional neuroimaging},
keywords = {Neurodevelopment},
keywords = {Children},
title = {Effects of Maternal Fish Oil and/or 5-MethylTetrahydrofolate Supplementation during Pregnancy on Offspring Brain Resting-State at 10 Years Old: A Follow-Up Study from the NUHEAL Randomized Controlled Trial},
doi = {10.3390/nu12092701},
author = {Azaryah, Hatim and Verdejo Román, Juan and Martín Pérez, Cristina and García Santos, José Antonio and Martínez-Zaldivar Moreno, Cristina and Torres Espinola, Francisco Jose and Campos, Daniel and Pérez García, Miguel and Catena Martínez, Andrés and Campoy Folgoso, Cristina},
}