@misc{10481/64145,
year = {2020},
month = {8},
url = {http://hdl.handle.net/10481/64145},
abstract = {Hydroxytyrosol (HT) from olives and polyphenols from almond skin (ASPs) possess cardioprotective properties. This pilot study evaluates the effect of supplementation with a combination of olive fruit and almond skin extracts on low-density lipoprotein (LDL) cholesterol oxidation, lipid homeostasis, and inflammatory parameters in adults with moderate hypercholesterolemia. A randomized, parallel, double-blind, placebo-controlled pilot study of 8 weeks was performed. The extract group (EG) received the supplement with 7.5 mg HT +210 mg ASPs, and the control group (CG) received a placebo composed of maltodextrin. Oxidized LDL (oxLDL) levels and the oxLDL/LDL ratio were lower in the EG than in the CG after 8 weeks of treatment (18.76 ± 3.91 vs. 10.34 ± 4.22, P < .001 and 0.151 ± 0.025 vs. 0.08 ± 0.023, P < .001, respectively). Interleukin-1β levels were significantly higher in the CG than in the EG at week 4 (P = .004), IL-6 was significantly higher in the CG than in the EG at week 4 (P = .049), and IL-10 was significantly increased at week 4 in both groups (P = .002 for CG and P = .001 for EG). In conclusion, daily consumption of a combination of an olive fruit extract and an almond skin extract for 8 weeks seems to protect LDL from oxidation and to prevent inflammatory status in moderately hypercholesterolemic subjects.},
organization = {Centre for the Development of Industrial Technology (CDTI)},
organization = {European Union (EU)
	
IDI_20190733},
publisher = {Mary Ann Liebert},
keywords = {Almond skin polyphenols},
keywords = {Atherosclerosis},
keywords = {Hydroxytyrosol},
keywords = {Inflammation},
keywords = {Oxidized low-density lipoprotein},
title = {Effects of a Combination of Extracts from Olive Fruit and Almonds Skin on Oxidative and Inflammation Markers in Hypercholesterolemic Subjects: A Randomized Controlled Trial},
doi = {10.1089/jmf.2020.0088},
author = {Fonolla Joya, Juristo and Maldonado Lobón, José Antonio and Luque, Roberto and Rodríguez, Carlos and Bañuelos Hortigüela, Óscar and López-Larramendi, José L. and Olivares, Mónica and Blanco-Rojo, Ruth},
}