@misc{10481/64100,
year = {2020},
month = {9},
url = {http://hdl.handle.net/10481/64100},
abstract = {Abstract
Objective: To investigate oxidative stress markers and antioxidants in bipolar disorder
(BD).
Methods: Electronic MEDLINE/PubMed/Cochrane-Library/Scopus/TripDatabase
search until 06/30/2019 for studies comparing antioxidant or oxidative stress markers
between BD and healthy controls (HCs). Standardized mean differences (SMD)
and 95% confidence intervals (CIs) were calculated for ≥3 studies.
Results: Forty-four studies (n = 3,767: BD = 1,979; HCs = 1,788) reported on oxidative
stress markers malondialdehyde (MDA), thiobarbituric acid reactive substances
(TBARS), and total nitrites; antioxidants glutathione (GSH), uric acid, and zinc; or antioxidantenhancing
enzymes superoxide dismutase (SOD), catalase (CAT), glutathione
peroxidase (GPX), and GSH-transferase (GST). Compared with HCs, BD was associated
with higher GST (P = .01), CAT (P = .02), nitrites (P < .0001), TBARS (P < .0001), MDA
(P = .01), uric acid (P < .0001), and lower GSH (P = .006), without differences in SOD,
GPX, and zinc. Compared to HCs, levels were higher in BD-mania for TBARS (P < .0001)
and uric acid (P < .0001); in BD-depression for TBARS (P = .02); and BD-euthymia for
uric acid (P = .03). Uric acid levels were higher in BD-mania vs BD-depression (P = .002),
but not vs BD euthymia. TBARS did not differ between BD-mania and BD-depression.
Medication-free BD-mania patients had higher SOD (P = .02) and lower GPX (P < .0001)
than HCs. After treatment, BD did not differ from HCs regarding SOD and GPX.
Conclusions: Beyond a single biomarker of oxidative stress, the combination of several
parameters appears to be more informative for BD in general and taking into
account illness polarity. BD is associated with an imbalance in oxidative stress with
some phase-specificity for uric acid and TBARS and possible treatment benefits for
SOD and GPX. Future studies should take into account confounding factors that can
modify oxidative stress status and simultaneously measure oxidative stress markers
and antioxidants including different blood sources.},
publisher = {Wiley},
keywords = {Antioxidants},
keywords = {Bipolar disorders},
keywords = {Meta-analysis},
keywords = {Oxidative stress},
keywords = {Polarity},
title = {Oxidative stress parameters and antioxidants in patients with bipolar disorder: Results from a meta-analysis comparing patients, including stratification by polarity and euthymic status, with healthy controls},
doi = {10.1111/bdi.12980},
author = {Jiménez Fernández, Sara and Gurpegui Fernández De Legaria, Manuel and Garrote Rojas, Daniel and Gutiérrez Rojas, Luis and Carretero, María D. and Correll, Christoph U.},
}