@misc{10481/64056,
year = {2020},
month = {8},
url = {http://hdl.handle.net/10481/64056},
abstract = {Increased levels of reactive oxygen species (ROS) and a low-grade chronic inflammation in
multiple organs have been demonstrated in obesity. Morus alba leaves extracts (MAEs) have been used
in traditional medicine as anti-inflammatory agents. In this work, the bioactive compounds of di erent
genotypes of M. alba L. (Filipina, Valenciana Temprana, Kokuso, and Italia) were analyzed not only by
reverse phase high performance liquid chromatography–electrospray ionization-time of flight-mass
spectrometry (RP-HPLC-ESI-TOF-MS) and hydrophilic interaction chromatography–electrospray
ionization-time of flight-mass spectrometry (HILIC-ESI-TOF-MS), but also screened for in vitro and
in vivo antioxidant activity by means of DPPH  radical scavenging assay and Caenorhabditis elegans
model. These MAEs were administered daily in a model of diet-induced obesity in mice. Filipina
and Italia genotypes significantly reduced weight gain, the glycemic levels in high fat diet, as well
as, levels of LDL-cholesterol and triglycerides. Filipina and Italia MAEs also reduced the expression
of proinflammatory mediators such as Tnf- , Il-1 , Il-6 and increased the levels of adiponectin and
AMPK, which exert anti-inflammatory e ects. Moreover, Italia genotype ameliorated the intestinal
barrier function. In conclusion, Filipina and Italia methanolic extracts show the highest antioxidant
and anti-inflammatory e ect, due to the presence of compounds such as protocatechuic acid or
quercetin-3-glucoside, and they could be developed as a complementary treatment for obesity and
metabolic disorders.},
organization = {Junta de Andalucia

CTS 164},
organization = {Spanish Ministry of Economy and Competitiveness 	
AGL2015-67995-C3-3-R},
organization = {European Commission (FEDER/ERDF)},
organization = {ERDF/FEDER Operational Programme of the Region of Murcia 	
2007ES161PO001
14-20/20},
organization = {Instituto de Salud Carlos III},
publisher = {Mdpi},
keywords = {Morus alba leaves},
keywords = {High fat diet},
keywords = {Obesity},
keywords = {Chemical characterization},
keywords = {Anti-inflammatory},
title = {Comparative Study of the Antioxidant and Anti-Inflammatory E ects of Leaf Extracts from Four Di erent Morus alba Genotypes in High Fat Diet-Induced Obesity in Mice},
doi = {10.3390/antiox9080733},
author = {Leyva Jiménez, Francisco Javier and Ruiz Malagón, Antonio Jesús and Molina Tijeras, José Alberto and Díez Echave, Patricia and Vezza, Teresa and Hidalgo García, Laura and Lozano Sánchez, Jesús and Arráez Román, David and Rodríguez Nogales, Alba and Segura Carretero, Antonio and Gálvez Peralta, Julio Juan},
}