@misc{10481/64049,
year = {2020},
month = {9},
url = {http://hdl.handle.net/10481/64049},
abstract = {Immunotherapy is a very promising therapeutic approach against cancer that is
particularly effective when combined with gene therapy. Immuno-gene therapy
approaches have led to the approval of four advanced therapy medicinal products
(ATMPs) for the treatment of p53-deficient tumors (Gendicine and Imlygic), refractory
acute lymphoblastic leukemia (Kymriah) and large B-cell lymphomas (Yescarta). In
spite of these remarkable successes, immunotherapy is still associated with severe
side effects for CD19+ malignancies and is inefficient for solid tumors. Controlling
transgene expression through an externally administered inductor is envisioned as a
potent strategy to improve safety and efficacy of immunotherapy. The aim is to develop
smart immunogene therapy-based-ATMPs, which can be controlled by the addition
of innocuous drugs or agents, allowing the clinicians to manage the intensity and
durability of the therapy. In the present manuscript, we will review the different inducible,
versatile and externally controlled gene delivery systems that have been developed and
their applications to the field of immunotherapy. We will highlight the advantages and
disadvantages of each system and their potential applications in clinics.},
organization = {Spanish ISCIII Health Research Fund},
organization = {European Union (EU)

PI12/01097
PI15/02015
PI18/00337
PI18/00330},
organization = {CECEyU},
organization = {CSyF of the Junta de Andalucia FEDER/European Cohesion Fund (FSE) for Andalusia 	
2016000073391-TRA
2016000073332-TRA
PI-57069
PAIDI-Bio326
PI-0014-2016},
organization = {Nicolas Monardes regional Ministry of Health 	
0006/2018},
organization = {Spanish Government

FPU16/05467
FPU17/02268},
organization = {MCI 	
DIN2018-010180},
publisher = {Frontiers Media SA},
keywords = {Immunotherapy},
keywords = {Gene therapy},
keywords = {Externally controlled},
keywords = {Inducible},
keywords = {Advanced therapy medicinal products (ATMPs)},
keywords = {Transgene expression},
keywords = {Cancer},
keywords = {Autoimmunity},
title = {Externally-Controlled Systems for Immunotherapy: From Bench to Bedside},
doi = {10.3389/fimmu.2020.02044},
author = {Tristán Manzano, María and Justicia Lirio, Pedro and Maldonado Pérez, Noelia and Cortijo Gutiérrez, Marina and Benabdellah, Karim and Martín, Francisco},
}