@misc{10481/63967,
year = {2012},
month = {11},
url = {http://hdl.handle.net/10481/63967},
abstract = {OBJECTIVE-Obesity is associatedwith a state of chronic low-grade inflammation.Myeloperoxidase (MPO) plays an important role in the initiation and progression of acute and chronic inflammatory diseases, such as cardiovascular disease (CVD). The objectives of the current study were to evaluate plasma MPO levels in prepubertal obese children and to determine whether MPO could be an early biomarker of inflammation and CVD risk.
RESEARCH DESIGN AND METHODS-In a prospective multicenter case-control
study paired by age and sex of 446 Caucasian prepubertal children ages 6–12 years, 223
normal-weight and 223 obese children were recruited. Blood pressure, waist circumference,
weight, and height were measured. In addition to MPO, glucose, insulin, metabolic lipid parameters, oxidized low-density lipoproteins, adiponectin, leptin, resistin, C-reactive protein (CRP), interleukin 6, tumor necrosis factor a, matrix metalloproteinase-9 (MMP-9), and plasminogen activator inhibitor 1 were determined.
RESULTS-We found that MPO was elevated in prepubertal obese children and that this
enzyme was associated with such proinflammatory and cardiovascular risk biomarkers as
CRP, MMP-9, and resistin. Insulin resistance calculated by the homeostatic assessment model
was the best predictor of MPO.
CONCLUSIONS-MPO is an early biomarker of inflammation associated with CVD risk in
obese children at the prepubertal age.},
organization = {Junta de Andalucía

CTS-2203},
organization = {Instituto de Salud Carlos III del Ministerio de Ciencia e Innovación Red SAMID RETIC 	
RD08/0072},
publisher = {Amer Diabetes Assoc},
title = {Myeloperoxidase Is an Early Biomarker of Inflammation and Cardiovascular Risk in Prepubertal Obese Children},
doi = {10.2337/dc12-0614},
author = {Olza Meneses, Josune and Aguilera García, Concepción María},
}