@misc{10481/63536,
year = {2020},
month = {7},
url = {http://hdl.handle.net/10481/63536},
abstract = {The objective of this study was to evaluate which hyperelastic model could best describe the nonlinear mechanical behavior of the cornea, in order to characterize the capability of the non-linear
model parameters to discriminate structural changes in a damaged cornea. Porcine corneas were
used, establishing two diferent groups: control (non-treated) and NaOH-treated (damaged) corneas
(n= 8). NaOH causes a chemical burn to the corneal tissue, simulating a disease associated to
structural damage of the stromal layer. Quasi-static uniaxial tensile tests were performed in nasaltemporal direction immediately after preparing corneal strips from the two groups. Three non-linear
hyperelastic models (i.e. Hamilton-Zabolotskaya model, Ogden model and Mooney-Rivlin model)
were ftted to the stress–strain curves obtained in the tensile tests and statistically compared. The
corneas from the two groups showed a non-linear mechanical behavior that was best described by
the Hamilton-Zabolotskaya model, obtaining the highest coefcient of determination (R2 > 0.95).
Moreover, Hamilton-Zabolotskaya model showed the highest discriminative capability of the nonlinear model parameter (Parameter A) for the tissue structural changes between the two sample
groups (p= 0.0005). The present work determines the best hyperelastic model with the highest
discriminative capability in description of the non-linear mechanical behavior of the cornea.},
organization = {Ministry of Education 	
DPI2017-83859-R
DPI2014-51870-R
EQC2018004508-P
UNGR15-CE-3664},
organization = {Ministry of Health - Turkey

DTS15/00093},
organization = {Junta de Andalucia

PI16/00339
PI-0107-2017
PIN-0030-2017},
publisher = {Nature Research},
title = {Characterization of non‑linear mechanical behavior of the cornea},
doi = {10.1038/s41598-020-68391-7},
author = {Ashofteh Yazdi, A. and Melchor, Juan and Torres, J. and Faris, Inas and Calleja, Alonso and Rus Carlborg, Guillermo},
}