@misc{10481/63430,
year = {2020},
month = {7},
url = {http://hdl.handle.net/10481/63430},
abstract = {The aim of this work was to optimize the recovery of phenolic compounds from
Lippia citriodora using supercritical fluid extraction (SFE). To achieve this goal, response surface
methodology based on a 23
central composite design was used to evaluate the effects of the following
experimental factors: temperature, pressure and co-solvent percentage. The effects of these variables
on the extraction yield and total polar compound contents were evaluated. With respect to the
phytochemical composition, an exhaustive individual phenolic compound quantitation was carried
out by HPLC-ESI-TOF-MS to analyze the functional ingredients produced by this system design.
To the best of our knowledge, this is the first time that a standardized supercritical fluid process has
been developed to obtain functional ingredients based on phenolic compounds from L. citriodora
in which the individual compound concentration was monitored over the different SFE conditions.
The results enabled the establishment of the optimal technical parameters for developing functional
ingredients and revealed the main factors that should be included in the extraction process control.
This functional food ingredient design could be used as a control system to be applied in nutraceutical
and functional food production industry.},
organization = {Ministry of Science, Innovation and Universities 	
RTI2018-096724-B-C22},
publisher = {MDPI},
keywords = {Lippia citriodora},
keywords = {Supercritical fluid extraction},
keywords = {HPLC-ESI-TOF-MS},
keywords = {Central composite design},
keywords = {Response surface methodology},
title = {Optimized Extraction of Phenylpropanoids and Flavonoids from Lemon Verbena Leaves by Supercritical Fluid System Using Response Surface Methodology},
doi = {doi:10.3390/foods9070931},
author = {Leyva Jiménez, Francisco Javier and Lozano Sánchez, Jesús and Fernández Ochoa, Álvaro and Cádiz Gurrea, María de la Luz and Arráez Román, David and Segura Carretero, Antonio},
}