@misc{10481/63425,
year = {2020},
month = {7},
url = {http://hdl.handle.net/10481/63425},
abstract = {Oxidative stress could help explain the relationship between childhood obesity and a
metabolically unhealthy (MU) status. Moreover, puberty could also influence this relationship,
since it entails physiological cardiometabolic changes. We aimed to evaluate plasma antioxidants
and oxidative stress biomarkers in MU and metabolically healthy (MH) prepubertal and pubertal
children and their associations with pro-inflammatory and endothelial damage biomarkers, taking
puberty into account. A total of 1444 Spanish children aged 3–17 years (48.9% males, 66% prepubertal,
47.1% with obesity) were recruited. Blood pressure, anthropometric and biochemical parameters
were measured, and children were categorized as having a MU or MH status according to risk factors.
Retinol, carotenes, tocopherols, total antioxidant capacity (TAC), oxidized low-density lipoprotein
and selected pro-inflammatory and endothelial damage biomarkers were analyzed. General linear
models adjusted for age, sex, recruitment center and body mass index, partial correlations and
stepwise linear regressions were performed. Lower carotenes and tocopherols levels were found in
MU than in MH children. Plasma TAC was lower in prepubertal and higher in pubertal children with
obesity compared to normal-weight children. Antioxidants and oxidative stress biomarkers showed
novel associations with several pro-inflammatory and endothelial damage biomarkers, with pubertal
differences, supporting the importance of considering both the antioxidant and oxidative stress status
and puberty in the prevention of metabolic diseases in childhood.},
organization = {Plan Nacional de Investigacion Cientifica, Desarrollo e Innovacion Tecnologica (I + D + I), Instituto de Salud Carlos III-Health Research Funding (FONDOS FEDER) 	
PI051968
PI11/01425
PI1102042
PI11/02059
PI16/01301
PI16/012
PI1600871},
organization = {CIBEROBN Network 	
CB12/03/30038
CB15/00131
CB15/00043},
publisher = {MDPI},
keywords = {Carotenoids},
keywords = {Tocopherols},
keywords = {Oxidized low-density lipoprotein},
keywords = {Inflammatory biomarkers},
keywords = {Childhood obesity},
keywords = {Metabolically healthy},
keywords = {Metabolic syndrome},
title = {Antioxidants and Oxidative Stress in Children: Influence of Puberty and Metabolically Unhealthy Status},
doi = {doi:10.3390/antiox9070618},
author = {Rupérez Cano, Azahara Iris and Mesa García, María Dolores and Anguita-Ruiz, Augusto and González Gil, Esther M. and Gil Hernández, Ángel and Aguilera García, Concepción María},
}