@misc{10481/63410,
year = {2020},
month = {7},
url = {http://hdl.handle.net/10481/63410},
abstract = {We aimed to study the association between occupational exposure to pesticides and
chronic lymphocytic leukemia (CLL) in Spain. Occupational exposure to pesticides (four insecticides,
four herbicides and two fungicides) was evaluated using a job-exposure matrix for the Spanish
population (MatEmESp) among 302 CLL cases and 1567 population controls in five regions of Spain,
2010–2013. Cumulative exposure scores (CES) were obtained by summing across the exposed jobs
the product of prevalence, intensity and duration of exposure to each active substance. Principal
components analysis (PCA) and logistic regression models adjusted for age, sex, region, education and
occupational exposure to solvents were used. Around 20% of controls and 29% of cases were exposed
to one or more pesticides. Compared to non-exposed, subjects in the highest tertile (3rd tertile) of
CES of insecticides, herbicides, fungicides were more likely to have CLL [OR (95% CI), P-trend;
2.10 (1.38; 3.19), 0.002; 1.77 (1.12; 2.80), 0.12; and 1.67 (1.06; 2.64), 0.10, respectively). Following PCA,
the first component (PC1, explaining 70% of the variation) equally led by seven active substances
(the insecticide pyrethrin, all herbicides, all fungicides) was associated with a 26% higher odds of
having CLL for 1-standard deviation increase in PC1 (95% CI: 1.14 to 1.40). These results confirm
previous associations between CLL and exposure to pesticides and provide additional evidence
by application groups and active substance. However, more research is needed to disentangle
independent effects of individual active substances.},
organization = {Spanish Ministry of Economy and Competitiveness-Carlos III Institute of Health},
organization = {European Union (EU)

PI08/1770
PI08/0533
PI08/1359
PS09/00773
PI11/01403
PI11/02213
PI14/1219
PI15/00966
PI17/01280
RTIC RD06/0020/0095
RD12/0036/0036
SV-09-CLINIC-1},
organization = {Instituto de Salud Carlos III

IJCI-2016-29502},
organization = {Instituto de Salud Carlos III

API 10/09},
organization = {Obra Social CAJASTUR (SV-CAJASTUR-1)},
organization = {La Caixa Foundation

2010ACUP 00310},
organization = {Secretariat for Universities and Research of the Ministry of Business and Knowledge of the Government of Catalonia 	
2017SGR1085},
organization = {Spanish Ministerio de Economia y Competitividad (MINECO) through the Instituto de Salud Carlos III (ISCIII) 	
PMP15/00007},
organization = {CIBERONC del ISCIII},
publisher = {MDPI},
keywords = {Pesticides},
keywords = {Job-exposure matrix},
keywords = {Chronic lymphocytic leukemia},
keywords = {Occupational exposure},
title = {Occupational Exposure to Pesticides and Chronic Lymphocytic Leukaemia in the MCC-Spain Study},
doi = {doi:10.3390/ijerph17145174},
author = {Benavente, Yolanda and Jiménez Moleón, José Juan},
}