@misc{10481/63404,
year = {2020},
month = {6},
url = {http://hdl.handle.net/10481/63404},
abstract = {Current chemotherapy for colorectal cancer (CRC) includes the use of oxaliplatin (Oxa),
a first-line cytotoxic drug which, in combination with irinotecan/5-fluorouracil or biologic agents,
increases the survival rate of patients. However, the administration of this drug induces side
effects that limit its application in patients, making it necessary to develop new tools for targeted
chemotherapy. MamC-mediated biomimetic magnetic nanoparticles coupled with Oxa (Oxa-BMNPs)
have been previously demonstrated to efficiently reduce the IC50 compared to that of soluble
Oxa. However, their strong interaction with the macrophages revealed toxicity and possibility of
aggregation. In this scenario, a further improvement of this nanoassembly was necessary. In the
present study, Oxa-BMNPs nanoassemblies were enveloped in phosphatidylcholine unilamellar
liposomes (both pegylated and non-pegylated). Our results demonstrate that the addition of both
a lipid cover and further pegylation improves the biocompatibility and cellular uptake of the
Oxa-BMNPs nanoassemblies without significantly reducing their cytotoxic activity in colon cancer
cells. In particular, with the pegylated magnetoliposome nanoformulation (a) hemolysis was reduced
from 5% to 2%, being now hematocompatibles, (b) red blood cell agglutination was reduced, (c) toxicity
in white blood cells was eliminated. This study represents a truly stepforward in this area as describes
the production of one of the very few existing nanoformulations that could be used for a local
chemotherapy to treat CRC.},
organization = {Ministerio de Economia y Competitividad from Spain 	
CGL2016-76723},
organization = {European Union (EU)

CGL2016-76723},
organization = {Junta de Andalucia

A-BIO-376-UGR18},
organization = {Unidad Cientifica de Excelencia of the University of Granada 	
UCE-PP2016-05},
organization = {Junta de Andalucia

PI-0102-2017},
organization = {Instituto de Salud Carlos III

European Union (EU)

PI19/01478},
organization = {Andalusian Government 	
CTS-107},
organization = {Ministerio de Educacion, Ciencia y Deporte y Competitividad (Spain) 	
FPU16_04580
FPU16_01716},
publisher = {MDPI},
keywords = {Biomimetics},
keywords = {Nanoparticles},
keywords = {Colon carcinoma},
keywords = {Liposomes},
keywords = {Oxaliplatin},
title = {Biomimetic Magnetoliposomes as Oxaliplatin Nanocarriers: In Vitro Study for Potential Application in Colon Cancer},
doi = {doi:10.3390/pharmaceutics12060589},
author = {García Pinel, Beatriz and Jabalera Ruz, Ylenia María and Ortiz, Raúl and Cabeza, Laura and Jiménez López, Concepción and Melguizo Alonso, Consolación and Prados Salazar, José Carlos},
}