@misc{10481/63274,
year = {2020},
month = {6},
url = {http://hdl.handle.net/10481/63274},
abstract = {Background: Exocrine pancreatic insufficiency results from the destruction of the pancreatic
parenchyma and is diagnosed by using direct or indirect tests, both of which have shortcomings.
Chronic pancreatitis is the most frequent cause of this pathology in adults. Methods: Patients meeting
radiological or histological diagnostic criteria of chronic pancreatitis are enrolled and the stool elastase
test is conducted, considering fecal elastase levels >200 µg/g to represent normal pancreatic function,
and levels <200 µg/g to indicate the presence of exocrine pancreatic insufficiency. Additionally,
we determine the body mass index of the patients and study their nutritional status and main
biochemical and hematological variables, including their glucose and hemoglobin A1c (HbA1c) levels.
Results: Exocrine pancreatic insufficiency is detected in 60% of the patients. Among these, 83.3% are
severe cases, and 72% of the latter also are diagnosed with endocrine pancreatic insufficiency (diabetes
mellitus). During the nutritional status study, HbA1c levels are significantly higher, and magnesium
and prealbumin levels are significantly lower in patients with exocrine pancreatic insufficiency than
in those without this disease. Conclusions: Exocrine and endocrine pancreatic insufficiency are highly
prevalent among patients with chronic pancreatitis and an early diagnosis of these diseases is vital to
improve the clinical management of these patients and reduce their risk of mortality.},
organization = {Junta de Andalucia

PC-0549-2017
PC-0498-2017},
publisher = {MDPI},
keywords = {Chronic pancreatitis},
keywords = {Exocrine pancreatic insufficiency},
keywords = {Diabetes mellitus},
keywords = {Nutritional status},
keywords = {Pancreatic complications},
title = {Role of Exocrine and Endocrine Insufficiency in the Management of Patients with Chronic Pancreatitis},
doi = {10.3390/jcm9062014},
author = {Diéguez Castillo, Carmelo and Jiménez Luna, Cristina and Martín Ruiz, José Luis and Martínez-Galán, Joaquina and Prados Salazar, José Carlos and Torres, Carolina and González Ramírez, Amanda Rocío and Caba Pérez, Octavio},
}