@misc{10481/63273,
year = {2020},
month = {6},
url = {http://hdl.handle.net/10481/63273},
abstract = {Polygenetic risk scores (pGRSs) consisting of adult body mass index (BMI) genetic
variants have been widely associated with obesity in children populations. The implication of
such obesity pGRSs in the development of cardio-metabolic alterations during childhood as well
as their utility for the clinical prediction of pubertal obesity outcomes has been barely investigated
otherwise. In the present study, we evaluated the utility of an adult BMI predisposing pGRS for the
prediction and pharmacological management of obesity in Spanish children, further investigating
its implication in the appearance of cardio-metabolic alterations. For that purpose, we counted
on genetics data from three well-characterized children populations (composed of 574, 96 and 124
individuals), following both cross-sectional and longitudinal designs, expanding childhood and
puberty. As a result, we demonstrated that the pGRS is strongly associated with childhood BMI
Z-Score (B = 1.56, SE = 0.27 and p-value = 1.90 × 10−8
), and that could be used as a good predictor of
obesity longitudinal trajectories during puberty. On the other hand, we showed that the pGRS is not
associated with cardio-metabolic comorbidities in children and that certain environmental factors
interact with the genetic predisposition to the disease. Finally, according to the results derived from a
weight-reduction metformin intervention in children with obesity, we discarded the utility of the
pGRS as a pharmacogenetics marker of metformin response.},
organization = {Plan Nacional de Investigacion Cientifica, Desarrollo e Innovacion Tecnologica (I + D + I), Instituto de Salud Carlos III-Health Research Funding (FONDOS FEDER) 	
PI1102042
PI1102059
PI1601301
PI1600871},
organization = {Spanish Ministry of Health, Social and Equality, General Department for Pharmacy and Health Products 	
EC10-243
EC10-056
EC10-281
EC10-227},
organization = {Regional Government of Andalusia ("Plan Andaluz de investigacion, desarrollo e innovacion (2018)") 	
P18-RT-2248},
organization = {Mapfre Foundation ("Research grants by Ignacio H. de Larramendi 2017")},
organization = {Instituto de Salud Carlos III

IFI17/00048},
publisher = {MDPI},
keywords = {Obesity},
keywords = {Childhood obesity},
keywords = {Metabolic syndrome},
keywords = {Genetics},
keywords = {Genetic risk score},
keywords = {Pharmacogenetics},
keywords = {Predictive ability},
keywords = {Gene-environment interactions},
keywords = {Puberty},
keywords = {Childhood},
keywords = {Spanish children},
title = {Evaluation of the Predictive Ability, Environmental Regulation and Pharmacogenetics Utility of a BMI-Predisposing Genetic Risk Score during Childhood and Puberty},
doi = {10.3390/jcm9061705},
author = {Anguita-Ruiz, Augusto and González Gil, Esther M. and Pastor-Villaescusa, Belén and Alcalá Fernández, Jesús and Gil Hernández, Ángel and Aguilera García, Concepción María},
}