@misc{10481/63265,
year = {2020},
month = {6},
url = {http://hdl.handle.net/10481/63265},
abstract = {Neutrophils are key cells of the immune system and have a decisive role in fighting foreign
pathogens in infectious diseases. Neutrophil extracellular traps (NETs) consist of a mesh of DNA
enclosing antimicrobial peptides and histones that are released into extracellular space following
neutrophil response to a wide range of stimuli, such as pathogens, host-derived mediators and
drugs. Neutrophils can remain functional after NET formation and are important for periodontal
homeostasis. Periodontitis is an inflammatory multifactorial disease caused by a dysbiosis state
between the gingival microbiome and the immune response of the host. The pathogenesis of
periodontitis includes an immune-inflammatory component in which impaired NET formation
and/or elimination can be involved, contributing to an exacerbated inflammatory reaction and to the
destruction of gingival tissue. In this review, we summarize the current knowledge about the role of
NETs in the pathogenesis of periodontitis.},
publisher = {MDPI},
keywords = {Innate immunity},
keywords = {Periodontitis},
keywords = {Neutrophil functions},
keywords = {Neutrophil extracellular traps},
title = {Neutrophil Extracellular Traps in Periodontitis},
doi = {10.3390/cells9061494},
author = {Magán Fernández, Antonio and Rasheed Al-Bakri, Sarmad Muayad and O'Valle Ravassa, Francisco Javier and Benavides Reyes, Cristina and Abadía Molina, Francisco and Mesa Aguado, Francisco Luis},
}