@misc{10481/63204,
year = {2020},
month = {6},
url = {http://hdl.handle.net/10481/63204},
abstract = {A terrestrial test system to investigate the biomagnifcation potential and tissue-specifc distribution
of ivermectin, a widely used parasiticide, in the non-target dung beetle Thorectes lusitanicus (Jekel)
was developed and validated. Biomagnifcation kinetics of ivermectin in T. lusitanicus was investigated
by following uptake, elimination, and distribution of the compound in dung beetles feeding on
contaminated faeces. Results showed that ivermectin was biomagnifed in adults of T. lusitanicus
when exposed to non-lethal doses via food uptake. Ivermectin was quickly transferred from the gut to
the haemolymph, generating a biomagnifcation factor (BMFk) three times higher in the haemolymph
than in the gut after an uptake period of 12 days. The fat body appeared to exert a major role on
the biomagnifcation of ivermectin in the insect body, showing a BMFk 1.6 times higher than in the
haemolymph. The results of this study highlight that the biomagnifcation of ivermectin should be
investigated from a global dung-based food web perspective and that the use of these antiparasitic
substances should be monitored and controlled on a precautionary basis. Thus, we suggest that an
additional efort be made in the development of standardised regulatory recommendations to guide
biomagnifcation studies in terrestrial organisms, but also that it is necessary to adapt existing methods
to assess the efects of such veterinary medical products.},
publisher = {Nature Research (part of Springer Nature)},
title = {Biomagnifcation and body distribution of ivermectin in dung beetles},
doi = {10.1038/s41598-020-66063-0},
author = {Verdú, José R. and Sánchez Piñero, Francisco},
}