@misc{10481/63162, year = {2014}, url = {http://hdl.handle.net/10481/63162}, abstract = {The Early Nutrition Academy supported a systematic review of human studies on the roles of pre- and postnatal long-chain polyunsaturated fatty acids (LC-PUFA) published from 2008 to 2013 and an expert workshop that reviewed the information and developed recommendations, considering particularly Asian populations. An increased supply of n-3 LC-PUFA during pregnancy reduces the risk of preterm birth before 34 weeks of gestation. Pregnant women should achieve an additional supply ≥200 mg docosahexaenic acid (DHA)/day, usually achieving a total intake ≥300 mg DHA/day. Higher intakes (600-800 mg DHA/day) may provide greater protection against early preterm birth. Some studies indicate beneficial effects of pre- and postnatal DHA supply on child neurodevelopment and allergy risk. Breast-feeding is the best choice for infants. Breast-feeding women should get ≥200 mg DHA/day to achieve a human milk DHA content of ∼0.3% fatty acids. Infant formula for term infants should contain DHA and arachidonic acid (AA) to provide 100 mg DHA/day and 140 mg AA/day. A supply of 100 mg DHA/day should continue during the second half of infancy. We do not provide quantitative advice on AA levels in follow-on formula fed after the introduction of complimentary feeding due to a lack of sufficient data and considerable variation in the AA amounts provided by complimentary foods. Reasonable intakes for very-low-birth weight infants are 18-60 mg/kg/day DHA and 18-45 mg/kg/day AA, while higher intakes (55-60 mg/kg/day DHA, ∼1% fatty acids; 35-45 mg/kg/day AA, ∼0.6-0.75%) appear preferable. Research on the requirements and effects of LC-PUFA during pregnancy, lactation, and early childhood should continue.}, organization = {DSM}, organization = {Mead Johnson Nutrition}, organization = {Wyeth Nutrition}, organization = {Sequoia}, organization = {Abbott Laboratories}, organization = {Danone}, organization = {Fonterra}, organization = {Hipp}, organization = {Mead Johnson}, organization = {Nestle}, organization = {European Commission Joint Research Centre}, organization = {Yakult Honsha Co., Ltd., Tokyo, Japan}, publisher = {Karger}, keywords = {Arachidonic acid}, keywords = {Eicosapentaenoic acid}, keywords = {Docosahexaenoic acid}, keywords = {Polyunsaturated fatty acids (PUFA)}, keywords = {Nutrition in pregnancy}, keywords = {Perinatal nutrition}, keywords = {Infant's feeding}, title = {Current Information and Asian Perspectives on Long-Chain Polyunsaturated Fatty Acids in Pregnancy, Lactation, and Infancy: Systematic Review and Practice Recommendations from an Early Nutrition Academy Workshop}, doi = {10.1159/000365767}, author = {Koletzko, Berthold and Campoy Folgoso, Cristina}, }