@misc{10481/63110,
year = {2020},
month = {5},
url = {http://hdl.handle.net/10481/63110},
abstract = {Increasing evidence connects periodontitis with a variety of systemic diseases, including
metabolic syndrome, atherosclerosis, and non-alcoholic fatty liver disease (NAFLD). The proposal of
this study was to evaluate the role of diets rich in saturated fat and cholesterol in some aspects of
periodontal diseases in a lipopolysaccharide (LPS)-induced model of periodontal disease in rabbits and
to assess the influence of a periodontal intervention on hyperlipidemia, atherosclerosis, and NAFLD
progression to non-alcoholic steatohepatitis. Male rabbits were maintained on a commercial standard
diet or a diet rich in saturated fat (3% lard w/w) and cholesterol (1.3% w/w) (HFD) for 40 days. Half of
the rabbits on each diet were treated 2 days per week with intragingival injections of LPS from
Porphyromonas gingivalis. Morphometric analyses revealed that LPS induced higher alveolar bone loss
(ABL) around the first premolar in animals receiving standard diets, which was exacerbated by the
HFD diet. A higher score of acinar inflammation in the liver and higher blood levels of triglycerides
and phospholipids were found in HFD-fed rabbits receiving LPS. These results suggest that certain
dietary habits can exacerbate some aspects of periodontitis and that bad periodontal health can
contribute to dyslipidemia and promote NAFLD progression, but only under certain conditions.},
organization = {Ministry of Education, Culture and Sport (Spain)},
organization = {Spanish Government},
organization = {Traslados Temporales FPU (University of Kings College of London)},
publisher = {MDPI},
keywords = {Atherogenic},
keywords = {Atherosclerosis},
keywords = {NASH},
keywords = {Non-alcoholic fatty liver disease},
keywords = {Periodontal diseases},
keywords = {Periodontitis},
keywords = {Rabbits},
title = {A Diet Rich in Saturated Fat and Cholesterol Aggravates the Effect of Bacterial Lipopolysaccharide on Alveolar Bone Loss in a Rabbit Model of Periodontal Disease},
doi = {10.3390/nu12051336},
author = {Varela López, Alfonso and Ramírez Tortosa, César Luis and Navarro Hortal, María Dolores and Quiles Morales, José Luis},
}