@misc{10481/63032,
year = {2020},
url = {http://hdl.handle.net/10481/63032},
abstract = {The heterogeneity of tinnitus is likely accounting for the lack of efective treatment approaches.
Headaches have been related to tinnitus, yet little is known on how headaches impact tinnitus. We
use cross-sectional data from the Swedish Tinnitus Outreach Project to i) evaluate the association
between headaches and tinnitus (n=1,984 cases and 1,661 controls) and ii) investigate the phenotypic
characteristics of tinnitus subjects with tinnitus (n=660) or without (n=1,879) headaches. In a
multivariable logistic regression model, headache was signifcantly associated with any tinnitus
(odds ratio, OR=2.61) and more so with tinnitus as a big problem (as measured by the tinnitus
functional index, TFI≥48; OR=5.63) or severe tinnitus (using the tinnitus handicap inventory,
THI ≥58; OR=4.99). When focusing on subjects with tinnitus, the prevalence of headaches was 26%
and reached 40% in subjects with severe tinnitus. A large number of socioeconomic, phenotypic and
psychological characteristics difered between headache and non-headache subjects with any tinnitus.
With increasing tinnitus severity, fewer diferences were found, the major ones being vertigo, neck
pain and other pain syndromes, as well as stress and anxiety. Our study suggests that headaches could
contribute to tinnitus distress and potentially its severity.},
organization = {GENDER-NET Co-Plus Fund 	
GNP-182},
organization = {Decibel Therapeutics, Inc.},
organization = {Svenska Lakaresallskapet 	
SLS-779681},
organization = {Tysta Skolan},
organization = {Horselforskningsfonden 	
503},
organization = {European Union's Horizon 2020 research and innovation programme under the Marie Skodowska-Curie grant 	
72204655},
organization = {Swedish Medical Research Council (SMRC)

K2014-99x-22478-01-3},
organization = {Karolinska Institutet},
publisher = {Nature Research (part of Springer Nature)},
title = {Relationship between headaches and tinnitus in a Swedish study},
doi = {10.1038/s41598-020-65395-1},
author = {López Escámez, José Antonio and Lugo, Alessandra},
}