@misc{10481/62779,
year = {2020},
month = {1},
url = {http://hdl.handle.net/10481/62779},
abstract = {Introduction
The relationship between benzodiazepines, opioids and tricyclic antidepressants and
trauma is of great importance because of increased consumption and the growing evidence
of a positive association among older adults. The objective of this study was to determine
the effect size of the association between the consumption of psychotropic medications /opioids and falls in patients who have suffered trauma by studying the role of other variables in
this relationship.
Method
From 2011 to 2016, the presence of benzodiazepines, opioids and tricyclic antidepressants
and other drugs in 1060 patients admitted for trauma at a level I trauma hospital was analysed. Multivariate models were used to measure the adjusted effect size of the association
between consumption of benzodiazepines, opioids and tricyclic antidepressants and falls,
and the effect of age on this association was studied.
Results
A total of 192 patients tested positive for benzodiazepines, opioids and tricyclic antidepressants, with same-level falls being the most frequent mechanism of injury in this group
(40.1%), with an odds ratio of 1.96 (1.40–2.75), p < 0.001. Once other covariates were introduced, this association was not observed, leaving only age, gender (woman) and, to a
lesser extent, sensory conditions as variables associated with falls. Age acted as an effect
modifier between benzodiazepines, opioids and tricyclic antidepressants and falls, with significant effect sizes starting at 51.9 years of age. 
Conclusions
The association between the consumption of benzodiazepines, opioids and tricyclic antidepressants and falls in patients admitted for trauma is conditioned by other confounding variables, with age being the most influential confounding variable.},
organization = {The members of the GISyC group (SCG,
CFA and ESM) are funded by “Programa Operativo
FEDER Extremadura (2014-2020) y Fondo Europeo
Desarrollo Regional (FEDER) Grant number:
GR18146. This work was supported by 4IE+
project (0499_4IE_PLUS_4_E) funded by the Interreg V-A España-Portugal (POCTEP) 2014-
2020 program.},
publisher = {Public Library of Science},
title = {Association of benzodiazepines, opioids and tricyclic antidepressants use and falls in trauma patients: Conditional effect of age},
doi = {10.1371/journal. pone.0227696},
author = {Cordovilla Guardia, Sergio Alejandro and Vilar López, Raquel},
}