@misc{10481/62487,
year = {2020},
url = {http://hdl.handle.net/10481/62487},
abstract = {Sweeteners that are a hundred thousand times sweeter than sucrose are being consumed as
sugar substitutes. The effects of sweeteners on gut microbiota composition have not been completely
elucidated yet, and numerous gaps related to the effects of nonnutritive sweeteners (NNS) on health still
remain. The NNS aspartame and acesulfame-K do not interact with the colonic microbiota, and, as a
result, potentially expected shifts in the gut microbiota are relatively limited, although acesulfame-K
intake increases Firmicutes and depletes Akkermansia muciniphila populations. On the other hand,
saccharin and sucralose provoke changes in the gut microbiota populations, while no health effects,
either positive or negative, have been described; hence, further studies are needed to clarify these
observations. Steviol glycosides might directly interact with the intestinal microbiota and need bacteria
for their metabolization, thus they could potentially alter the bacterial population. Finally, the effects of
polyols, which are sugar alcohols that can reach the colonic microbiota, are not completely understood;
polyols have some prebiotics properties, with laxative effects, especially in patients with inflammatory
bowel syndrome. In this review, we aimed to update the current evidence about sweeteners’ effects
on and their plausible biological interactions with the gut microbiota.},
publisher = {MDPI},
keywords = {Nonnutritive sweeteners},
keywords = {Sweetening agents},
keywords = {Gut microbiota},
title = {Plausible Biological Interactions of Low- and Non-Calorie Sweeteners with the Intestinal Microbiota: An Update of Recent Studies},
doi = {doi:10.3390/nu12041153},
author = {Plaza Díaz, Julio and Pastor-Villaescusa, Belén and Rueda Robles, Ascensión and Abadía Molina, Francisco and Ruiz Ojeda, Francisco Javier},
}