@misc{10481/62486,
year = {2020},
month = {4},
url = {http://hdl.handle.net/10481/62486},
abstract = {This cross-sectional study aimed to examine the association of basal metabolic rate (BMR)
and basal fat and carbohydrate oxidation (BFox and BCHox, respectively) with cardiometabolic
risk factors and insulin sensitivity in sedentary middle-aged adults. A total of 71 healthy sedentary
adults (37 women) aged 40–65 years participated in the current study. Data were collected during
the baseline assessments of the FIT-AGEING randomized controlled trial. BMR was measured via
indirect calorimetry, and BFox and BCHox estimated by stoichiometric equations. Blood pressure,
glucose, insulin, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein
cholesterol, and triglycerides plasma levels were selected as cardiometabolic risk factors and assessed
following standard procedures. We observed positive associations of BMR with plasma insulin and
the homeostatic model assessment of insulin resistance index (HOMA; all p < 0.05) which were
attenuated or disappeared after controlling by sex, age, and/or lean mass. There were positive
associations between BFox and the quantitative insulin sensitivity check index (QUICKI; p < 0.015),
while negative associations were noted between BFox and plasma insulin and HOMA (p < 0.015).
There was a significant negative association between BCHox with QUICKI (p < 0.01), whereas
significant positive relationships were obtained when BCHox was associated with plasma insulin
and HOMA (p < 0.01). These associations persisted in almost all cases when controlling by sex,
age and/or lean mass. No further relationships were found when BMR, BFox, and BCHox were
associated with other cardiometabolic risk factors. In conclusion, our study findings support that
greater BFox and lower BCHox are related to improved insulin sensitivity, whereas BMR seems to be
not associated with neither cardiometabolic risk nor insulin sensitivity in sedentary middle-aged
adults. Further intervention studies are necessary to well-understand the physiological mechanism
implied in this relationship.},
organization = {The study is supported by the Spanish Ministry of Education (FPU14/04172 and FPU15/03960), the Redes
Temáticas de Investigación Cooperativa RETIC network (Red SAMID RD16/0022), the University of Granada’s Plan
Propio de Investigación 2016 - Excellence actions: Unit of Excellence on Exercise and Health (UCEES), the Junta de
Andalucía, Consejería de Conocimiento, Investigación y Universidades, European Regional Development Funds
(ERDF, SOMM17/6107/UGR).},
publisher = {MDPI},
keywords = {Metabolic rate},
keywords = {Basal metabolism},
keywords = {Fat oxidation},
keywords = {Carbohydrate oxidation},
keywords = {Indirect calorimetry},
keywords = {Cardiometabolic risk},
keywords = {Energy balance},
keywords = {Insulin resistance},
title = {Association of Basal Metabolic Rate and Nutrients Oxidation with Cardiometabolic Risk Factors and Insulin Sensitivity in Sedentary Middle-Aged Adults},
doi = {doi:10.3390/nu12041186},
author = {Amaro Gahete, Francisco José and Jurado Fasoli, Lucas and Ruiz Ruiz, Jonatan and Castillo Garzón, Manuel},
}