@misc{10481/62459,
year = {2020},
url = {http://hdl.handle.net/10481/62459},
abstract = {We have designed and synthesized two novel cobalt coordination compounds using
bumetanide (bum) and indomethacin (ind) therapeutic agents. The anti-inflammatory effects of
cobalt metal complexes with ind and bum were assayed in lipopolysaccharide stimulated RAW
264.7 macrophages by inhibition of nitric oxide production. Firstly, we determined the cytotoxicity
and the anti-inflammatory potential of the cobalt compounds and ind and bum ligands in RAW
264.7 cells. Indomethacin-based metal complex was able to inhibit the NO production up to 35%
in a concentration-dependent manner without showing cytotoxicity, showing around 6–37 times
more effective than indomethacin. Cell cycle analysis showed that the inhibition of NO production
was accompanied by a reversion of the differentiation processes in LPS-stimulated RAW 264.7 cells,
due to a decreased of cell percentage in G0/G1 phase, with the corresponding increase in the number
of cells in S phase. These two materials have mononuclear structures and show slow relaxation
of magnetization. Moreover, both compounds show anti-diabetic activity with low in vitro cell
toxicities. The formation of metal complexes with bioactive ligands is a new and promising strategy
to find new compounds with high and enhanced biochemical properties and promises to be a field of
great interest.},
organization = {This work has been funded by Junta de Andalucía (FQM-394 and FQM-1484),
the Spanish Ministry of Economy and Competitiveness (MCIU/AEI/FEDER, UE) (PGC2018-102052-A-C22,
PGC2018-102052-B-C21, and PGC2018-102047-B-I00) and Red Guipuzcoana de Ciencia, Tecnología e Innovación
(OF188/2017), University of the Basque Country (GIU 17/13). The authors thank for technical and human support
provided by SGIker of UPV/EHU and European funding (ERDF and ESF).},
publisher = {MDPI},
keywords = {Bumetadine},
keywords = {Indomethacin},
keywords = {Cobalt},
keywords = {Coordination compounds},
keywords = {Single ion magnet},
keywords = {Inflammatory},
keywords = {Diabetes},
title = {Designing Single-Molecule Magnets as Drugs with Dual Anti-Inflammatory and Anti-Diabetic Effects},
doi = {doi:10.3390/ijms21093146},
author = {Navas, Arturo and Jannus, Fatin and Fernández, Belén and Medina-O'Donnell, Marta and Díaz Ruiz, Luis and Sánchez González, Cristina and Llopis González, Juan and Rufino Palomares, Eva and Lupiáñez Cara, José Antonio and Quiles Morales, José Luis and Reyes Zurita, Fernando Jesús and Rodríguez Diéguez, Antonio},
}