@misc{10481/62433,
year = {2020},
month = {4},
url = {http://hdl.handle.net/10481/62433},
abstract = {The adoption of multiscale approaches by the biomechanical community has caused a major
improvement in quality in the mechanical characterization of soft tissues. The recent developments in
elastography techniques are enabling in vivo and non-invasive quantification of tissues’ mechanical
properties. Elastic changes in a tissue are associated with a broad spectrum of pathologies, which
stems from the tissue microstructure, histology and biochemistry. This knowledge is combined with
research evidence to provide a powerful diagnostic range of highly prevalent pathologies, from birth
and labor disorders (prematurity, induction failures, etc.), to solid tumors (e.g., prostate, cervix,
breast, melanoma) and liver fibrosis, just to name a few. This review aims to elucidate the potential
of viscous and nonlinear elastic parameters as conceivable diagnostic mechanical biomarkers.
First, by providing an insight into the classic role of soft tissue microstructure in linear elasticity;
secondly, by understanding how viscosity and nonlinearity could enhance the current diagnosis
in elastography; and finally, by compounding preliminary investigations of those elastography
parameters within different technologies. In conclusion, evidence of the diagnostic capability of
elastic parameters beyond linear stiffness is gaining momentum as a result of the technological
and imaging developments in the field of biomechanics.},
organization = {This research was funded by Ministerio de Educación, Cultura y Deporte grant numbers
DPI2017-83859-R, DPI2014-51870-R, UNGR15-CE-3664 and EQC2018-004508-P; Ministerio de Sanidad, Servicios
Sociales e Igualdad grant numbers DTS15/00093 and PI16/00339; Instituto de Salud Carlos III y Fondos Feder;
Junta de Andalucía grant numbers PI-0107-2017, PIN-0030-2017 and IE2017-5537; Juan de la Cierva Incorporación
IJC2018-037167-I, Ministerio de Ciencia, Innovación y Universidades grant number PRE2018-086085.},
publisher = {MDPI},
keywords = {Elastography},
keywords = {Soft tissue},
keywords = {Nonlinearity},
keywords = {Viscoelasticity},
title = {Why Are Viscosity and Nonlinearity Bound to Make an Impact in Clinical Elastographic Diagnosis?},
doi = {doi:10.3390/s20082379},
author = {Rus Carlborg, Guillermo and Faris, Inas and Torres, Jorge and Callejas Zafra, Antonio Manuel and Melchor, Juan},
}