@misc{10481/62378, year = {2020}, url = {http://hdl.handle.net/10481/62378}, abstract = {Considered to be a major portal of entry for infectious agents, the oral cavity is directly associated with the evolutionary process of SARS-CoV-2 in its inhalation of ambient particles in the air and in expectorations. Some new generations of mouth rinses currently on the market have ingredients that could contribute to lower the SARS-CoV-2 viral load, and thus facilitate the fight against oral transmission. If chlorhexidine, a usual component of mouth rinse, is not efficient to kill SARS-CoV-2, the use of a mouth rinses and/or with local nasal applications that contain β-cyclodextrins combined with flavonoids agents, such as Citrox, could provide valuable adjunctive treatment to reduce the viral load of saliva and nasopharyngeal microbiota, including potential SARS-CoV-2 carriage. We urge national agencies and authorities to start clinical trials to evaluate the preventive effects of βCD-Citrox therapeutic oral biofilm rinses in reducing the viral load of the infection and possibly disease progression.}, publisher = {MDPI}, keywords = {COVID-19}, keywords = {2019-nCoV}, keywords = {SARS-CoV-2}, keywords = {Oral cavity}, keywords = {Mouthrinse}, keywords = {β-cyclodextrins}, keywords = {Citrox}, keywords = {Viral load}, keywords = {Microbiome}, title = {COVID-19: A Recommendation to Examine the Effect of Mouthrinses with β-Cyclodextrin Combined with Citrox in Preventing Infection and Progression}, doi = {doi:10.3390/jcm9041126}, author = {Llodra Calvo, Juan Carlos and Carrouel, Florence}, }