@misc{10481/62372,
year = {2020},
url = {http://hdl.handle.net/10481/62372},
abstract = {The aim of this study was to examine whether metabolically healthy overweight/obese
children have greater global and regional gray matter volumes than their metabolically unhealthy
peers. We further examined the association between gray matter volume and academic achievement,
along with the role of cardiorespiratory fitness in these associations. A total of 97 overweight/obese
children (10.0 ± 1.2 years) participated. We classified children as metabolically healthy/unhealthy
based on metabolic syndrome cut-offs. Global and regional brain volumes were assessed by magnetic
resonance imaging. Academic achievement was assessed using the Woodcock-Muñoz standardized
test. Cardiorespiratory fitness was assessed by the 20 m shuttle run test. Metabolically healthy
overweight/obese (MHO) children had greater regional gray matter volume compared to those
who were metabolically unhealthy (MUO) (all p ≤ 0.001). A similar trend was observed for global
gray matter volume (p = 0.06). Global gray matter volume was positively related to academic achievement (β = 0.237, p = 0.036). However, all the associations were attenuated or disappeared
after adjusting for cardiorespiratory fitness (p > 0.05). The findings of the present study support that
metabolically healthy overweight/obese children have greater gray matter volume compared to those
that are metabolically unhealthy, which is in turn related to better academic achievement. However,
cardiorespiratory fitness seems to explain, at least partially, these findings.},
organization = {The ActiveBrains project was funded by the Spanish Ministry of Economy and Competitiveness and the "Fondo Europeo de Desarrollo Regional (FEDER)" (DEP2013-47540, DEP2016-79512-R, DEP2017-91544-EXP and RYC-2011-09011). CC-S are supported by the Government of Andalusian, Integrated Territorial Initiative 2014-2020 for the province of Cadiz (PI-0002-2017) and the Spanish Ministry of Science and Innovation (FJC2018-037925-I). IE-C are supported by the Alicia Koplowitz Foundation and the Spanish Ministry of Economy and Competitiveness (RTI2018-095284-J-100). JHM and JM-G are supported by the Spanish Ministry of Education, Culture and Sport (FPU15/02645 and FPU14/06837, respectively). JVR is supported by a grant from the Spanish Ministry of Science, Innovation and Universities (FJCI-2017-33396). PH was supported by a grant from the Strategic Research Area Health Care Science, Karolinska Institutet/Umea University. Additional funding was obtained from the University of Granada, Plan Propio de Investigacion 2016, Excellence actions: Units of Excellence; Scientific Excellence Unit on Exercise and Health (UCEES). Junta de Andalucia, Consejeria de Conocimiento, Investigacion y Universidades and European Regional Development Funds (ref. SOMM17/6107/UGR). In addition, funding was provided by the SAMID III network, RETICS, funded by the PN I + D + I 2017-2021 (Spain), ISCIII-Sub-Directorate General for Research Assessment and Promotion, the European Regional Development Fund (ERDF) (Ref. RD16/0022), the EXERNET Research Network on Exercise and Health in Special Populations (DEP2005-00046/ACTI) and the European Union's 2020 research and innovation program under grant agreement No 667302.},
publisher = {MDPI},
keywords = {Academic achievement},
keywords = {Cardiorespiratory fitness},
keywords = {Global volume},
keywords = {Gray matter},
keywords = {Regional volume},
title = {Differences in Brain Volume between Metabolically Healthy and Unhealthy Overweight and Obese Children: The Role of Fitness},
doi = {doi: 10.3390/jcm9041059]},
author = {Cadenas Sánchez, Cristina and Esteban Cornejo, Irene and Migueles Hidalgo, Jairo and Verdejo Román, Juan and Mora González, José Rafael and Kramer, Arthur F. and Catena Martínez, Andrés and Ortega Porcel, Francisco Bartolomé},
}