@misc{10481/62356,
year = {2020},
month = {4},
url = {http://hdl.handle.net/10481/62356},
abstract = {This study investigated physical activity (PA) and sedentary time (SED) in relation to
hippocampal gray matter volume (GMV) in pediatric overweight/obesity. Ninety-three children
(10 ± 1 year) were classified as overweight, obesity type I, or type II–III. PA was assessed with
non-dominant wrist accelerometers. GMV was acquired by magnetic resonance imaging (MRI).
Neither PA nor SED associated with GMV in the hippocampus in the whole sample (p > 0.05).
However, we found some evidence of moderation by weight status (p < 0.150). Moderate-to-vigorous
PA (MVPA) positively associated with GMV in the right hippocampus in obesity type I (B = 5.62,
p = 0.017), which remained when considering SED, light PA, and sleep using compositional data
(γ = 375.3, p = 0.04). Compositional models also depicted a negative association of SED relative to
the remaining behaviors with GMV in the right hippocampus in overweight (γ = −1838.4, p = 0.038).
Reallocating 20 min/day of SED to MVPA was associated with 100 mm3 GMV in the right hippocampus
in obesity type I. Multivariate pattern analysis showed a negative-to-positive association pattern
between PA of increasing intensity and GMV in the right hippocampus in obesity type II–III. Our
findings support that reducing SED and increasing MVPA are associated with greater GMV in the
right hippocampus in pediatric overweight/obesity. Further studies should corroborate our findings.},
organization = {MINECO/FEDER 	
DEP2013-47540
DEP2016-79512-R
RYC-2011-09011},
organization = {Spanish Ministry of Education, Culture and Sport 	
FPU15/02645
FPU17/04802},
organization = {Government of Andalusian, Integrated Territorial Initiative 2014-2020 for the province of Cadiz 	
PI-0002-2017},
organization = {Spanish Government

FJC2018-037925-I},
organization = {Alicia Koplowitz Foundation},
organization = {Spanish Ministry of Economy and Competitiveness 	
RTI2018-095284-J-100},
organization = {University of Granada, Plan Propio de Investigacion 2016, Excellence actions: Units of Excellence},
organization = {Scientific Excellence Unit on Exercise and Health (UCEES)},
organization = {Junta de Andalucia},
organization = {Consejeria de Conocimiento, Investigacion y Universidades},
organization = {European Union (EU)},
organization = {SAMID III network, RETICS - PN I + D+I 2017-2021 (Spain)},
organization = {ISCIII-Sub-Directorate General for Research Assessment and Promotion},
organization = {European Union (EU)

RD16/0022},
organization = {EXERNET Research Network on Exercise and Health in Special Populations 	
DEP2005-00046/ACTI},
publisher = {MDPI},
keywords = {Physical behavior},
keywords = {Sedentary behavior},
keywords = {Brain health},
keywords = {Youth},
keywords = {Pre-adolescent},
title = {Associations of Objectively-Assessed Physical Activity and Sedentary Time with Hippocampal Gray Matter Volume in Children with Overweight/Obesity},
doi = {10.3390/jcm9041080},
author = {Migueles Hidalgo, Jairo and Cadenas Sánchez, Cristina and Esteban Cornejo, Irene and Torres López, Lucía Victoria and Ortega Porcel, Francisco Bartolomé},
}