@misc{10481/62341,
year = {2020},
month = {4},
url = {http://hdl.handle.net/10481/62341},
abstract = {Purpose

Schemes with high doses per fraction and small number of fractions are commonly used in high-dose-rate brachytherapy (HDR-BT) for prostate cancer. Our aim was to analyze the differences between published clinical results and the predictions of radiobiological models for absorbed dose required in a single fraction monotherapy HDR-BT.
Material and methods

Published HDR-BT clinical results for low- and intermediate-risk patients with prostate cancer were revised. For 13 clinical studies with 16 fractionation schedules between 1 and 9 fractions, a dose-response relation in terms of the biochemical control probability (BC) was established using Monte Carlo-based statistical methods.
Results

We obtained a value of α/β = 22.8 Gy (15.1-60.2 Gy) (95% CI) much larger than the values in the range 1.5-3.0 Gy that are usually considered to compare the results of different fractionation schemes in prostate cancer radiotherapy using doses per fraction below 6 Gy. The doses in a single fraction producing BC = 90% and 95% were 22.3 Gy (21.5-24.2 Gy) and 24.3 Gy (23.0-27.9 Gy), respectively.
Conclusions

The α/β obtained in our analysis of 22.8 Gy for a range of dose per fraction between 6 and 20.5 Gy was much greater than the one currently estimated for prostate cancer using low doses per fraction. This high value of α/β explains reasonably well the data available in the region of high doses per fraction considered.},
organization = {Spanish Ministerio de Ciencia y Competitividad 	
FPA2015-67694-P},
organization = {European Union (EU)},
organization = {Junta de Andalucía
	
FQM0387},
publisher = {Termedia Publishing},
keywords = {HDR brachytherapy},
keywords = {Prostate cancer},
keywords = {Monotherapy},
title = {A radiobiological study of the schemes with a low number of fractions in high-dose-rate brachytherapy as monotherapy for prostate cancer},
doi = {10.5114/jcb.2020.94492},
author = {Guirado Llorente, Damián and Ruiz-Arrebola, Samuel and Tornero-López, Ana M. and de la Vega, Jose M. and Prada, Pedro J. and Lallena Rojo, Antonio Miguel},
}