@misc{10481/62179,
year = {2019},
month = {4},
url = {http://hdl.handle.net/10481/62179},
abstract = {Objective: This study aimed to examine whether brown adipose tissue (BAT) or skeletal muscle activity
mediates the relationship between personal level of environmental temperature (Personal-ET) and wrist skin
temperature (WT). Moreover, we examined whether BAT and skeletal muscle have a mediating role between
Personal-ET and WT (as a proxy of peripheral vasoconstriction/vasodilation).
Methods: The levels of BAT were quantified by cold-induced 18F-fluorodeoxyglucose–positron emission
tomography/computed tomography scan and measured the Personal-ET and WT by using iButtons (Maxim
Integrated, Dallas, Texas) in 75 participants (74.6% women).
Results: The study found that BAT volume and metabolic activity played a positive and significant role (up
to 25.4%) in the association between Personal-ET and WT. In addition, at the coldest temperatures, the
participants with lower levels of WT (inducing higher peripheral vasoconstriction) had higher levels of BAT
outcomes, whereas in warm temperatures, participants with higher levels of WT (inducing higher peripheral
vasodilation) had lower levels of BAT outcomes. The study did not find any mediating role of skeletal muscle
activity.
Conclusions: BAT volume and metabolic activity play a role in the relationship between Personal-ET and
WT. Moreover, the data suggest that there are two distinct phenotypes: individuals who respond better to
the cold, both through nonshivering thermogenesis and peripheral vasoconstriction, and individuals who
respond better to the heat.},
organization = {This study was supported by the Spanish Ministry of Economy and Competitiveness, Fondo de Investigación Sanitaria del Instituto de Salud Carlos III (PI13/01393), Retos de la Sociedad (DEP2016‐79512‐R), and Fondos Estructurales de la Unión Europea (FEDER); by the Spanish Ministry of Education (FPU 13/04365); by the Fundación Iberoamericana de Nutrición; by the Redes Temáticas de Investigación Cooperativa RETIC (Red SAMID RD16/0022); by AstraZeneca HealthCare Foundation; by the University of Granada, Plan Propio de Investigación 2016, Excellence actions: Units of Excellence; Unit of Excellence on Exercise and Health (UCEES); and by the Junta de Andalucía, Consejería de Conocimiento, Investigación y Universidades and European Regional Development Fund (ERDF), ref. SOMM17/6107/UGR, Programa Contratos‐Puente. MAR is supported by a predoctoral research grant from University Jaume I (PREDOC/2015/13). AMN was supported by the Ministry of Economy and Competitiveness, the Instituto de Salud Carlos III through the Centro de Investigación Biomédica en Red Fragilidad y Envejecimiento Saludable (CB16/10/00239), and grant 19899/GERM/15 (cofinanced by FEDER).},
publisher = {Wiley},
title = {The Mediating Role of Brown Fat and Skeletal Muscle Measured by 18F-Fluorodeoxyglucose in the Thermoregulatory System in Young Adults},
doi = {10.1002/oby.22461},
author = {Martínez Téllez, Borja Manuel and Acosta Manzano, Francisco Miguel and Sánchez-Delgado, Guillermo and Llamas Elvira, José Manuel and Ruiz Ruiz, Jonatan},
}