@misc{10481/62026,
year = {2019},
month = {3},
url = {http://hdl.handle.net/10481/62026},
abstract = {Cerebellar Purkinje cells mediate accurate eye movement coordination. However, it remains
unclear how oculomotor adaptation depends on the interplay between the characteristic
Purkinje cell response patterns, namely tonic, bursting, and spike pauses. Here, a spiking
cerebellar model assesses the role of Purkinje cell firing patterns in vestibular ocular reflex
(VOR) adaptation. The model captures the cerebellar microcircuit properties and it incorporates
spike-based synaptic plasticity at multiple cerebellar sites. A detailed Purkinje cell
model reproduces the three spike-firing patterns that are shown to regulate the cerebellar
output. Our results suggest that pauses following Purkinje complex spikes (bursts) encode
transient disinhibition of target medial vestibular nuclei, critically gating the vestibular signals
conveyed by mossy fibres. This gating mechanism accounts for early and coarse VOR
acquisition, prior to the late reflex consolidation. In addition, properly timed and sized Purkinje
cell bursts allow the ratio between long-term depression and potentiation (LTD/LTP) to
be finely shaped at mossy fibre-medial vestibular nuclei synapses, which optimises VOR
consolidation. Tonic Purkinje cell firing maintains the consolidated VOR through time.
Importantly, pauses are crucial to facilitate VOR phase-reversal learning, by reshaping previously
learnt synaptic weight distributions. Altogether, these results predict that Purkinje
spike burst-pause dynamics are instrumental to VOR learning and reversal adaptation.},
organization = {This work was supported by the
European Union (www.europa.eu), Project SpikeControl 658479 (recipient NL), the Spanish
Agencia Estatal de Investigacio´n and European
Regional Development Fund (www.ciencia.gob.es/
portal/site/MICINN/aei), Project CEREBROT
TIN2016-81041-R (recipient ER), and the French
National Research Agency (www.agence-nationalerecherche.
fr) – Essilor International (www.essilor.
com), Chair SilverSight ANR-14-CHIN-0001
(recipient AA).},
publisher = {PLOS},
title = {Spike burst-pause dynamics of Purkinje cells regulate sensorimotor adaptation},
doi = {10.1371/journal.pcbi.1006298},
author = {Luque, Nieto R. and Naveros Arrabal, Francisco and Carrillo Sánchez, Richard Rafael and Ros Vidal, Eduardo and Arleo, Angelo},
}