@misc{10481/61938,
year = {2019},
month = {6},
url = {http://hdl.handle.net/10481/61938},
abstract = {Vestibular Migraine (VM) and Meniere’s Disease (MD) are episodic vestibular syndromes
defined by a set of associated symptoms such as tinnitus, hearing loss or migraine
features during the attacks. Both conditions may show symptom overlap and there is
no biological marker to distinguish them. Two subgroups of MD patients have been
reported, according to their IL-1b profile. Therefore, considering the clinical similarity
between VM and MD, we aimed to investigate the cytokine profile of MD and VM
as a means to distinguish these patients. We have also carried out gene expression
microarrays and measured the levels of 14 cytokines and 11 chemokines in 129 MD
patients, 82 VM patients, and 66 healthy controls. Gene expression profile in peripheral
blood mononuclear cells (PBMC) showed significant differences in MD patients with high
and low basal levels of IL- 1b and VMpatients.MD patients with high basal levels of IL- 1b
(MDH) had overall higher levels of cytokines/chemokines when compared to the other
subsets. CCL4 levels were significantly different between MDH, MD with low basal levels
of IL- 1b (MDL), VM and controls. Logistic regression identified IL- 1b, CCL3, CCL22, and
CXCL1 levels as capable of differentiating VM patients from MD patients (area under the
curve = 0.995), suggesting a high diagnostic value in patients with symptoms overlap.},
organization = {This work was supported by PI13/1242 and PI17/1644 Grant
from ISCIII by FEDER Funds from the EU. Marisa Flook is
funded by FI18/00228 from ISCIII.},
publisher = {Frontiers in Media},
keywords = {Vestibular Migraine},
keywords = {Meniere Disease},
keywords = {Differential diagnosis},
title = {Differential Proinflammatory Signature in Vestibular Migraine and Meniere Disease},
doi = {10.3389/fimmu.2019.01229},
author = {Flook, Marisa and Frejo, Lidia and Espinosa Sánchez, Juan Manuel and Pérez Carpena, Patricia and López Escámez, José Antonio},
}