@misc{10481/61801,
year = {2020},
month = {1},
url = {http://hdl.handle.net/10481/61801},
abstract = {Ischemia-reperfusion (I/R) injury is an unresolved problem in liver resection and
transplantation. The preexisting nutritional status related to the gut microbial profile might contribute
to primary non-function after surgery. Clinical studies evaluating artificial nutrition in liver resection
are limited. The optimal nutritional regimen to support regeneration has not yet been exactly defined.
However, overnutrition and specific diet factors are crucial for the nonalcoholic or nonalcoholic
steatohepatitis liver diseases. Gut-derived microbial products and the activation of innate immunity
system and inflammatory response, leading to exacerbation of I/R injury or impaired regeneration
after resection. This review summarizes the role of starvation, supplemented nutrition diet, nutritional
status, and alterations in microbiota on hepatic I/R and regeneration. We discuss the most updated
effects of nutritional interventions, their ability to alter microbiota, some of the controversies, and
the suitability of these interventions as potential therapeutic strategies in hepatic resection and
transplantation, overall highlighting the relevance of considering the extended criteria liver grafts in
the translational liver surgery.},
organization = {This research was supported by the Ministerio de Ciencia, Innovacion y Universidades
(RTI2018-095114-B-I00) Madrid, Spain; European Union (Fondos Feder, “una manera de hacer Europa”); CERCA
Program/Generalitat de Catalunya and Secretaria d’Universitats I Recerca del Departament d’Economia I
Coneixement (2017 SGR-551) Barcelona, Spain.},
publisher = {MDPI},
keywords = {Ischemia-reperfusion injury},
keywords = {Nutritional status},
keywords = {Supplemented nutrition},
keywords = {Gut microbiota},
keywords = {Partial hepatectomy},
title = {Current Knowledge about the Effect of Nutritional Status, Supplemented Nutrition Diet, and Gut Microbiota on Hepatic Ischemia-Reperfusion and Regeneration in Liver Surgery},
doi = {10.3390/nu12020284},
author = {Cornide Petronio, María Eugenia and Álvarez Mercado, Ana Isabel and Jiménez Castro, Mónica B. and Peralta, Carmen},
}