@misc{10481/61780,
year = {2020},
month = {2},
url = {http://hdl.handle.net/10481/61780},
abstract = {During the first days of life, premature infants have physiological difficulties swallowing,
thereby missing out on the benefits of breastfeeding. The aim of this study is to assess the effects of
oropharyngeal mother’s milk administration in the inflammatory signaling of extremely premature
infants. Neonates (n = 100) (<32 week’s gestation and/or <1500 g) were divided into two groups:
mother’s milk group (n = 48), receiving 0.2 mL of oropharyngeal mother’s milk every 4 h for the
first 15 days of life, and a control group (n = 52), not receiving oropharyngeal mother’s milk. Serum
concentrations of interleukin (IL) IL-6, IL-8, IL-10, IL-1ra, tumor necrosis factor alpha (TNF-a),
and interferón gamma (IFN-
y) were assessed at 1, 3, 15, and 30 days of postnatal life. Maternal and
neonatal outcomes were collected. The rate of common neonatal morbidities in both groups was
similar. The mother’s milk group achieved full enteral feeding earlier, and showed a decrease in Il-6
on days 15 and 30, in IL-8 on day 30, and in TNF-a and INF-
y on day 15, as well as an increase in IL-1ra
on days 3 and 15 and in IL-10 on day 30. Oropharyngeal mother’s milk administration for 15 days
decreases the pro-inflammatory state of preterm neonates and provides full enteral nutrition earlier,
which could have a positive influence on the development of the immune system and inflammatory
response, thereby positively influencing other developmental outcomes.},
publisher = {MDPI},
keywords = {Colostrum administration},
keywords = {Premature neonates},
keywords = {Clinical outcomes},
keywords = {Inflammation},
title = {Oropharyngeal Colostrum Positively Modulates the Inflammatory Response in Preterm Neonates},
doi = {10.3390/nu12020413},
author = {Martínez Álvarez, Estefanía and Díaz Castro, Javier and Peña Caballero, Manuela and Serrano López, Laura and Moreno Fernández, Jorge and Sánchez Martínez, Belén and Martín Peregrina, Francisca and Alonso Moya, Mercedes and Maldonado Lozano, José and Hurtado Suazo, José Antonio and Ochoa Herrera, Julio José},
}