@misc{10481/61776,
year = {2020},
month = {2},
url = {http://hdl.handle.net/10481/61776},
abstract = {Skeletal muscle plays a relevant role in metabolic flexibility and fuel usage and the
associated muscle metabolic inflexibility due to high-fat diets contributing to obesity and type 2
diabetes. Previous research from our group indicates that a high-fat and rapid-digesting carbohydrate
diet during pregnancy promotes an excessive adipogenesis and also increases the risk of non-alcoholic
fatty liver disease in the offspring. This effect can be counteracted by diets containing carbohydrates
with similar glycemic load but lower digestion rates. To address the role of the skeletal muscle in
these experimental settings, pregnant rats were fed high-fat diets containing carbohydrates with
similar glycemic load but different digestion rates, a high fat containing rapid-digesting carbohydrates
diet (HF/RD diet) or a high fat containing slow-digesting carbohydrates diet (HF/SD diet). After
weaning, male offspring were fed a standard diet for 3 weeks (weaning) or 10 weeks (adolescence)
and the impact of the maternal HF/RD and HF/SD diets on the metabolism, signaling pathways
and muscle transcriptome was analyzed. The HF/SD offspring displayed better muscle features
compared with the HF/RD group, showing a higher muscle mass, myosin content and differentiation
markers that translated into a greater grip strength. In the HF/SD group, metabolic changes such
as a higher expression of fatty acids (FAT/CD36) and glucose (GLUT4) transporters, an enhanced
glycogen content, as well as changes in regulatory enzymes such as muscle pyruvate kinase and
pyruvate dehydrogenase kinase 4 were found, supporting an increased muscle metabolic flexibility
and improved muscle performance. The analysis of signaling pathways was consistent with a better
insulin sensitivity in the muscle of the HF/SD group.},
organization = {This research was funded by European Union’s Seventh Framework Programme (FP7/2007–2013):
project Early Nutrition, under grant agreement no. 289346.},
publisher = {MDPI},
keywords = {Early programming},
keywords = {Skeletal muscle},
keywords = {Muscle differentiation},
keywords = {Insulin-resistant pregnancy},
keywords = {Metabolic flexibility},
keywords = {Slow digesting carbohydrates},
title = {Programming Skeletal Muscle Metabolic Flexibility in Offspring of Male Rats in Response to Maternal Consumption of Slow Digesting Carbohydrates during Pregnancy},
doi = {10.3390/nu12020528},
author = {Salto González, Rafael and Girón González, María Dolores and Manzano, Manuel and Martín, María J. and Vílchez, José D. and Bueno-Vargas, Pilar and Cabrera, Elena and Pérez Alegre, Mónica and Andújar, Eloisa and Rueda Valdivia, Ricardo and López-Pedrosa, José M.},
}