@misc{10481/61764, year = {2020}, month = {2}, url = {http://hdl.handle.net/10481/61764}, abstract = {Aim: The aim of this study was to explore associations of urinary concentrations of bisphenols A (BPA), S (BPS), and F (BPF) and of thiobarbituric acid reactive substances (TBARS) with the risk of endometriosis in women of childbearing age. Results: After adjustment for urinary creatinine, age, BMI, parity, and residence, endometriosis risk was increased with each 1 log unit of BPA [OR 1.5; 95%CI 1.0–2.3] and Sbisphenols [OR 1.5; 95%CI 0.9–2.3] but was not associated with the presence of BPS and BPF. Classification of the women by tertiles of exposure revealed statistically significant associations between endometriosis risk and the second tertile of exposure to BPA [OR 3.7; 95%CI 1.3–10.3] and Sbisphenols [OR 5.4; 95%CI 1.9–15.6]. In addition, TBARS concentrations showed a close-to-significant relationship with increased endometriosis risk [OR 1.6; 95%CI 1.0–2.8], and classification by TBARS concentration tertile revealed that the association between endometriosis risk and concentrations of BPA [OR 2.0; 95%CI 1.0–4.1] and Sbisphenols [OR 2.2; 95%CI 1.0–4.6] was only statistically significant for women in the highest TBARS tertile (>4.23 uM). Conclusion: Exposure to bisphenols may increase the risk of endometriosis, and oxidative stress may play a crucial role in this association. Further studies are warranted to verify these findings.}, organization = {Instituto de Salud Carlos III: PI17/01743; Instituto de Salud Carlos III: PI16/01820; Instituto de Salud Carlos III: PI16/01812; Instituto de Salud Carlos III: PI16/01858; Instituto de Salud Carlos III: PI17/01526; Instituto de Salud Carlos III: IFI18/00052; Instituto de Salud Carlos III: FI17/00316; Instituto de Salud Carlos III: INT18/00060; European Commission: H2020-EJP-HBM4EU.}, publisher = {MDPI}, keywords = {Endocrine disruption}, keywords = {Bisphenol-A}, keywords = {Bisphenol-F}, keywords = {Bisphenol-S}, title = {Association of Urinary Levels of Bisphenols A, F, and S with Endometriosis Risk: Preliminary Results of the End EA Study}, doi = {10.3390/ijerph17041194}, author = {Martín Peinado, Francisco and Lendínez Romero, Inmaculada and Sotelo, Rafael and Iribarne Durán, Luz María and Fernández Parra, Jorge and Vela Soria, Fernando and Olea Serrano, Nicolás and Fernández Cabrera, Mariana Fátima and Freire, Carmen and León, Josefa and Pérez Cabrera, Beatriz and Ocón Hernández, Olga and Artacho Cordón, Francisco}, }