@misc{10481/61669,
year = {2019},
month = {4},
url = {http://hdl.handle.net/10481/61669},
abstract = {Nucleopeptides represent an intriguing class of nucleic acid analogues, in which nucleobases
are placed in a peptide structure. The incorporation of D- and/or L-amino acids in nucleopeptide
molecules allows the investigation of the role of backbone stereochemistry in determining the
formation of DNA and RNA hybrids. Circular Dichroism (CD) spectroscopic studies indicated the
nucleopeptide as having fully l-backbone configuration-formed stable hybrid complexes with RNA
molecules. Molecular Dynamics (MD) simulations suggested a potential structure of the complex
resulting from the interaction between the l-nucleopeptide and RNA strand. From this study, both the
backbone (ionics and H-bonds) and nucleobases (pairing and pi-stacking) of the chiral nucleopeptide
appeared to be involved in the hybrid complex formation, highlighting the key role of the backbone
stereochemistry in the formation of the nucleopeptide/RNA complexes.},
organization = {This research was supported by Scientific Independence of Young Researchers (SIR) 2014 (RBSI142AMA)
and University of Campania Luigi Vanvitelli (Valere) to S.D.M.},
publisher = {MDPI},
keywords = {Nucleic acids},
keywords = {Nucleopeptides},
keywords = {Backbone stereochemistry},
keywords = {Solid-phase synthesis},
keywords = {Molecular dynamic simulation},
title = {Investigation of the Stereochemical-Dependent DNA and RNA Binding of Arginine-Based Nucleopeptides},
doi = {10.3390/sym11040567},
author = {Tomassi, Stefano and Franco Montalbán, Francisco and Russo, Rosita and Novellino, Ettore and Messere, Anna and Di Maro, Salvatore},
}