@misc{10481/61652,
year = {2019},
month = {8},
url = {http://hdl.handle.net/10481/61652},
abstract = {S‐klotho, the shed form of α‐klotho, is thought to be an ageing suppressor with functions related to the
physiology of energy metabolism. However, it remains unknown whether ageing biomarkers such as S‐klotho
and/or chronological ageing are associated in any way with basal metabolic rate (BMR) and fuel oxidation in
basal conditions and during exercise. The present work investigates the association of BMR and fuel oxidation
in basal conditions and during exercise, with plasma S‐klotho in middle‐aged, sedentary adults. BMR was
measured by indirect calorimetry in 74 such subjects (53% women; age 53.7±5.1 years) following standard
procedures, and their fuel oxidation estimated via stoichiometric equations. The maximal fat oxidation during
exercise (MFO) and the intensity of exercise that elicits MFO (Fatmax) were determined using a walking graded
exercise test. No relationship was seen between BMR and plasma S‐klotho (P>0.1), although both basal fat
oxidation and MFO showed positive associations with this protein (both P<0.001); these relationships persisted
after controlling for age, sex and fat mass. However, no significant associations were seen between BMR, basal
fat oxidation or MFO and chronological age (all P>0.1). The present findings suggest that basal fat oxidation and
MFO are strongly associated with plasma S‐klotho in middle‐aged sedentary adults. These results support the
idea that metabolic flexibility is a powerful predictor of biological ageing.},
organization = {The study was supported by the Spanish Ministry of
Education (FPU14/04172 and FPU15/03960), by the
University of Granada Plan Propio de Investigación
2016 (Excellence actions: Unit of Excellence on
Exercise and Health [UCEES]), by the Junta de
Andalucía, Consejería de Conocimiento, Investigación
y Universidades, and the European Regional
Development Fund (ERDF), ref. SOMM17/6107/UGR.},
publisher = {Impact Journals LLC},
keywords = {Basal fat oxidation},
keywords = {Basal metabolic rate},
keywords = {Aging},
keywords = {MFO},
title = {Association of basal metabolic rate and fuel oxidation in basal conditions and during exercise, with plasma S‐klotho: the FIT‐AGEING study},
author = {Amaro Gahete, Francisco José and De la O Puerta, Alejandro and Jurado Fasoli, Lucas and Ruiz Ruiz, Jonatan and Castillo, Manuel J.},
}