@misc{10481/61428, year = {2019}, month = {3}, url = {http://hdl.handle.net/10481/61428}, abstract = {Chagas disease caused by the protozoan parasite Trypanosoma cruzi represents a significant public health problem in Latin America, affecting around 8 million cases worldwide. Nowadays is urgent the identification of new antichagasic agents as the only therapeutic options available, Nifurtimox and Benznidazole, are in use for>40 years, and present high toxicity, limited efficacy and frequent treatment failures in the chronic phase of the disease. Recently, it has been described the antiparasitic effect of AS-48, a bacteriocin produced by Enterococcus faecalis, against Trypanosoma brucei and Leishmania spp. In this work, we have demonstrated the in vitro potential of the AS-48 bacteriocin against T. cruzi. Interesting, AS-48 was more effective against the three morphological forms of different T. cruzi strains, and displayed lower cytotoxicity than the reference drug Benznidazole. In addition, AS-48 combines the criteria established as a potential antichagasic agent, resulting in a promising therapeutic alternative. According to the action mechanism, AS-48 trypanocidal activity could be explained in a mitochondrion-dependent manner through a reactive oxygen species production and mitochondrial depolarization, causing a fast and severe bioenergetic collapse.}, organization = {This work was supported by the Spanish Ministry of Economy and Competitiveness [grant numbers SAF2013-48971-C2-1-R, CSD2010- 00065], both including funds from the European Regional Development Fundings (ERDF), and the Ministry of Education of Spain [RM-E, grant number FPU14/01537].}, publisher = {Elsevier Inc.}, keywords = {Antichagasic agent}, keywords = {Drug discovery}, keywords = {Trypanosoma cruzi}, keywords = {AS-48}, title = {Insights into Chagas treatment based on the potential of bacteriocin AS-48}, doi = {10.1016/j.ijpddr.2019.03.003}, author = {Martín-Escolano, Rubén and Cebrián, Rubén and Martín Escolano, Javier and Rosales Lombardo, María José and Maqueda Abreu, Mercedes and Sánchez Moreno, Manuel and Marín Sánchez, Clotilde}, }