@misc{10481/61428,
year = {2019},
month = {3},
url = {http://hdl.handle.net/10481/61428},
abstract = {Chagas disease caused by the protozoan parasite Trypanosoma cruzi represents a significant public health problem
in Latin America, affecting around 8 million cases worldwide. Nowadays is urgent the identification of new
antichagasic agents as the only therapeutic options available, Nifurtimox and Benznidazole, are in use for>40
years, and present high toxicity, limited efficacy and frequent treatment failures in the chronic phase of the
disease. Recently, it has been described the antiparasitic effect of AS-48, a bacteriocin produced by Enterococcus
faecalis, against Trypanosoma brucei and Leishmania spp. In this work, we have demonstrated the in vitro potential
of the AS-48 bacteriocin against T. cruzi. Interesting, AS-48 was more effective against the three morphological
forms of different T. cruzi strains, and displayed lower cytotoxicity than the reference drug Benznidazole. In
addition, AS-48 combines the criteria established as a potential antichagasic agent, resulting in a promising
therapeutic alternative. According to the action mechanism, AS-48 trypanocidal activity could be explained in a
mitochondrion-dependent manner through a reactive oxygen species production and mitochondrial depolarization,
causing a fast and severe bioenergetic collapse.},
organization = {This work was supported by the Spanish Ministry of Economy and
Competitiveness [grant numbers SAF2013-48971-C2-1-R, CSD2010-
00065], both including funds from the European Regional Development
Fundings (ERDF), and the Ministry of Education of Spain [RM-E, grant
number FPU14/01537].},
publisher = {Elsevier Inc.},
keywords = {Antichagasic agent},
keywords = {Drug discovery},
keywords = {Trypanosoma cruzi},
keywords = {AS-48},
title = {Insights into Chagas treatment based on the potential of bacteriocin AS-48},
doi = {10.1016/j.ijpddr.2019.03.003},
author = {Martín-Escolano, Rubén and Cebrián, Rubén and Martín Escolano, Javier and Rosales Lombardo, María José and Maqueda Abreu, Mercedes and Sánchez Moreno, Manuel and Marín Sánchez, Clotilde},
}