@misc{10481/61416,
year = {2020},
month = {2},
url = {http://hdl.handle.net/10481/61416},
abstract = {The increase in life expectancy and the increasing prevalence of diabetic disease and venous
insufficiency lead to the increase of chronic wounds. The prevalence of ulcers ranges from 1% in
the adult population to 3–5% in the over 65 years population, with 3–5.5% of the total healthcare
expenditure, as recently estimated. The aim of this work was the design and the development
of electrospun scaffolds, entirely based on biopolymers, loaded with montmorillonite (MMT) or
halloysite (HNT) and intended for skin reparation and regeneration, as a 3D substrate mimicking the
dermal ECM. The scaffolds were manufactured by means of electrospinning and were characterized
for their chemico-physical and preclinical properties. The scaffolds proved to possess the capability
to enhance fibroblast cells attachment and proliferation with negligible proinflammatory activity.
The capability to facilitate the cell adhesion is probably due to their unique 3D structure which are
assisting cell homing and would facilitate wound healing in vivo.},
organization = {This work was partially supported by Horizon 2020 Research and Innovation Programme under Grant
Agreement No. 814607},
publisher = {MDPI},
keywords = {Chondroitin sulfate},
keywords = {Electrospinning},
keywords = {Fibroblasts proliferation},
keywords = {Immune response},
keywords = {Chitosan},
keywords = {Scaffolds},
title = {Halloysite- and Montmorillonite-Loaded Scaffolds as Enhancers of Chronic Wound Healing},
doi = {10.3390/pharmaceutics12020179},
author = {Sandri, Giuseppina and Aguzzi, Carola and Viseras Iborra, César Antonio},
}