@misc{10481/61179,
year = {2020},
url = {http://hdl.handle.net/10481/61179},
abstract = {Procedures: We measured 125 individuals after a personalized cooling protocol with a static
[18F]FDG-PET/CT scan. We quantified BAT using different combination of threshold in every
single HU for all participants.
Results: We observed that the SUV threshold influences BAT quantification by [18F]FDG-PET/
CT scans more than the HU range. We found that the range from − 50 to − 10 HU had the
highest proportion of total BAT volume (43.2 %), which represents 41.4 % of the total BAT
metabolic activity in our cohort. We also observed that BAT volume was not different between
categories of body mass index, as well as BAT activity (SUVmean). In addition, BAT was less
dense in women than in men, although the BAT activity (SUVmean) was higher in all ranges of
HU. We also observed that the radiodensity of BAT located in the cervical area was mainly in the
range from − 50 to − 10 HU.
Conclusion: Therefore, all future human studies using static [18F]FDG-PET/CT scans should
include BAT in the radiodensity range from − 50 to − 10 HU.},
organization = {This study was supported by the Spanish Ministry of Economy and Competitiveness,
Fondo de Investigación Sanitaria del Instituto de Salud Carlos III
(PI13/01393) and Retos de la Sociedad (DEP2016-79512-R), Fondos
Estructurales de la Unión Europea (FEDER), by the Spanish Ministry of
Education (FPU 13/04365), by the Fundación Iberoamericana de Nutrición
(FINUT), the Redes Temáticas de Investigación Cooperativa RETIC (Red
SAMID RD16/0022), the AstraZeneca HealthCare Foundation, the University
of Granada Plan Propio de Investigación 2016 - Excellence actions:
Unit of Excellence on Exercise and Health (UCEES) - and Plan Propio de
Investigación 2018 - Programa Contratos-Puente, and the Junta de
Andalucía, Consejería de Conocimiento, Investigación y Universidades
(FEDER, ref. SOMM17/6107/UGR).},
publisher = {Springer Nature},
keywords = {Brown fat},
keywords = {Hounsfield units},
keywords = {Standardized uptake value},
keywords = {Cold exposure},
title = {Distribution of Brown Adipose Tissue Radiodensity in Young Adults: Implications for Cold [18F]FDG-PET/CT Analyses},
doi = {10.1007/s11307-019-01381-y},
author = {Martínez Téllez, Borja Manuel and Sánchez-Delgado, Guillermo and Boon, Mariëtte R. and Rensen, Patrick C. N. and Llamas Elvira, José Manuel and Ruiz Ruiz, Jonatan},
}