@misc{10481/61121,
year = {2019},
url = {http://hdl.handle.net/10481/61121},
abstract = {The use of antimicrobials in human and veterinary
medicine has coincided with a rise in antimicrobial
resistance (AMR) in the food-borne pathogens
Campylobacter jejuni and Campylobacter coli.
Faecal contamination from the main reservoir hosts
(livestock, especially poultry) is the principal route of
human infection but little is known about the spread of
AMR among source and sink populations. In particular,
questions remain about how Campylobacter resistomes
interact between species and hosts, and the potential
role of sewage as a conduit for the spread of AMR. Here,
we investigate the genomic variation associated with
AMR in 168 C. jejuni and 92 C. coli strains isolated from
humans, livestock and urban effluents in Spain. AMR
was tested in vitro and isolate genomes were sequenced
and screened for putative AMR genes and alleles. Genes
associated with resistance to multiple drug classes were
observed in both species and were commonly present in
multidrug-resistant genomic islands (GIs), often located
on plasmids or mobile elements. In many cases, these
loci had alleles that were shared among C. jejuni and
C. coli consistent with horizontal transfer. Our results
suggest that specific antibiotic resistance genes have
spread among Campylobacter isolated from humans,
animals and the environment.},
organization = {S.K.S., B.P. and S.C.B. were supported by grants from the
Medical Research Council (MR/L015080/1), the Wellcome
Trust (088786/C/09/Z), the Food Standards Agency
(FS246004) and the Biotechnology and Biological Sciences
Research Council (BB/I02464X/1). E.M. received a University of Bath Faculty of Science URSA studentship. D.F.C. is
supported by the FPI program (BES-2013-065003) from the
Spanish Ministry of Economy and Competitiveness. J.K.C. is
supported by a BBSRC KTN PhD studentship (BB/P504750/1).},
publisher = {Society for applied microbiology},
title = {Gene pool transmission of multidrug resistance among Campylobacter from livestock, sewage and human disease},
doi = {10.1111/1462-2920.14760},
author = {Mourkas, Evangelos and Gutiérrez Fernández, José},
}