@misc{10481/60895,
year = {2019},
url = {http://hdl.handle.net/10481/60895},
abstract = {Aims: To analyze the clinical relevance of O6-methylguanine-DNA methyltransferase in rectal adenocarcinoma treated with chemoradiotherapy followed by surgery.
Methods: Tissue samples from 29 rectal adenocarcinoma patients were obtained after chemoradiotherapy. O6-methylguanine-DNA methyltransferase promoter methylation status was established by methylation-specific polymerase chain reaction. O6-methylguanine-DNA methyltransferase protein levels were determined by immunohistochemistry. Clinicopathologic variables, including treatment regression grade, recurrence, lymph node invasion, and stage and differentiation grade of the tumor, were determined.
Results: The O6-methylguanine-DNA methyltransferase gene promoter was methylated in 81.5% of samples. Most patients (88.9%) showed low O6-methylguanine-DNA methyltransferase protein expression. O6-methylguanine-DNA methyltransferase methylation status was not correlated with any of the clinicopathological variables determined in rectal adenocarcinomas selected for chemoradiotherapy.
Conclusion: O6-methylguanine-DNA methyltransferase methylation status is not correlated with clinicopathologic variables examined in rectal adenocarcinoma selected for chemoradiotherapy, although its role as a biomarker awaits further investigation.},
publisher = {Trakya Universitesi; Galenos Publishing House},
keywords = {Chemoradiotherapy},
keywords = {O6-methylguanine-DNA methyltransferase},
keywords = {Rectal adenocarcinoma},
title = {O6-methylguanine-DNA Methyltransferase Promoter Methylation in Patients with Rectal Adenocarcinoma After Chemoradiotherapy Treatment: Clinical Implications},
doi = {10.4274/balkanmedj.galenos.2019.2018.12.93},
author = {Oliver Esteve, Jaime Antonio and Cabeza Montilla, Laura and Perazzoli, Gloria and Jiménez Luna, Cristina and Doello, Kevin and Ortiz Quesada, Raúl},
}