@misc{10481/60720,
year = {2019},
month = {12},
url = {http://hdl.handle.net/10481/60720},
abstract = {Background: Several studies have explored the role of human
brown adipose tissue (BAT) in energy expenditure. However, the link
between BAT and appetite regulation needs to be more rigorously
examined.
Objective: We aimed to investigate the associations of BAT volume
and 18F-fluordeoxyglucose (18F-FDG) uptake after a personalized
cold exposure with energy intake and appetite-related sensations in
young healthy humans.
Methods: A total of 102 young adults (65 women; age: 22.08 ± 2.17
y; BMI: 25.05 ± 4.93 kg/m 2) took part in this cross-sectional
study. BAT volume, BAT 18F-FDG uptake, and skeletal muscle 18FFDG
uptake were assessed by means of static 18F-FDG positronemission
tomography and computed tomography scans after a 2-h
personalized exposure to cold. Energy intake was estimated via an
objectively measured ad libitum meal and three nonconsecutive 24-h
dietary recalls. Appetite-related sensations (i.e., hunger and fullness)
were recorded by visual analog scales before and after a standardized
breakfast (energy content = 50% of basal metabolic rate) and the
ad libitum meal. Body composition was assessed by a whole-body
DXA scan.
Results: BAT volume and 18F-FDG uptake were not associated
with quantified ad libitum energy intake (all P > 0.088), nor with
habitual energy intake estimated from the 24-h dietary recalls (all
P > 0.683). Lean mass was positively associated with both the
energy intake from the ad libitum meal (β: 17.612, R2 = 0.213;
P < 0.001) and the habitual energy intake (β: 16.052, R2 = 0.123;
P = 0.001). Neither the interaction BAT volume × time elapsed
after meal consumption nor that of BAT 18F-FDG uptake × time
elapsed after meal consumption had any significant influence on
appetite-related sensations after breakfast or after meal consumption
(all P > 0.3).
Conclusions: Neither BAT volume, nor BAT 18F-FDG uptake after
cold stimulation, are related to appetite regulation in young adults.
These results suggest BAT plays no important role in the regulation of
energy intake in humans. This trial was registered at clinicaltrials.gov
as NCT02365129.},
organization = {Fondo de Investigación Sanitaria del Instituto de Salud Carlos III grant PI13/01393 (to JRR)},
organization = {Retos de la Sociedad grant DEP2016-79512-R (to JRR)},
organization = {Redes Temáticas de Investigación Cooperativa grant Red SAMID RD16/0022 (to AG)},
organization = {Junta de Andalucía, Consejería de Conocimiento, Investigación y Universidadesgrant SOMM17/6107/UGR (to JRR) via the ERDF.},
publisher = {Oxford University Press},
keywords = {Brown fat},
keywords = {Thermogenesis},
keywords = {Appetite},
keywords = {Energy balance},
keywords = {Obesity},
title = {Brown adipose tissue volume and 18F-fluorodeoxyglucose uptake are not associated with energy intake in young human adults},
doi = {10.1093/ajcn/nqz300},
author = {Sánchez-Delgado, Guillermo and Acosta Manzano, Francisco Miguel and Martínez Téllez, Borja Manuel and Finlayson, Graham and Gibbons, Catherine and Labayen, Idoia and Llamas Elvira, José Manuel and Gil Hernández, Ángel and Blundell, John E. and Ruiz Ruiz, Jonatan},
}