@misc{10481/60193,
year = {2018},
month = {8},
url = {http://hdl.handle.net/10481/60193},
abstract = {The structure of the human skin is directly dependent on its location and the mechanical forces to which it is subjected. In
the present work, we have performed a comprehensive analysis of the human ridged and non-ridged skin to identify the
differences and similarities between both skin types. For this purpose, human skin samples were obtained from dorsal hand
skin (DHS), palmar hand skin (PHS), dorsal foot skin (DFS) and plantar foot skin (PFS) from the same cadaveric donors.
Histological, histochemical and semiquantitative and quantitative immunohistochemical analyses were carried out to evaluate
the epidermis, dermis and basement membrane. Results show that the epithelial layer of ridged skin had larger cell number
and size than non-ridged skin for most strata. Melanocytes and Langerhans cells were more abundant in non-ridged skin,
whereas Merkel cells were preferentially found in ridged skin. The expression pattern of CK5/6 was slightly differed between
non-ridged and ridged skin. Involucrin expression was slightly more intense in non-ridged skin than in ridged skin. Collagen
was more abundant in foot skin dermis than in hand skin, and in ridged skin as compared to non-ridged skin. Elastic fibers
were more abundant in DHS. Biglycan was more abundant in foot skin than in hand skin. No differences were found for
blood and lymphatic vessels. The basement membrane laminin was preferentially found in foot skin. These results revealed
important differences at the epithelial, dermal and basement membrane levels that could contribute to a better knowledge
of the human skin histology.},
organization = {This work was partially supported by Award no.
AC17/00013 (NanoGSkin) by ISCIII thorough AES 2017 and within
the EuroNanoMed framework.},
publisher = {Springer Nature},
keywords = {Quantitative analysis},
keywords = {Non-ridged skin},
keywords = {Ridged skin},
keywords = {Glabrous skin},
keywords = {Palmoplantar skin},
keywords = {Immunohistochemistry},
title = {Characterization of the human ridged and non-ridged skin: a comprehensive histological, histochemical and immunohistochemical analysis},
doi = {10.1007/s00418-018-1701-x},
author = {Vela Romera, Alejandro Manuel and Carriel Araya, Víctor and Martín Piedra, Miguel Ángel and Aneiros-Fernández, José and Campos Sánchez, Fernando and Chato Astrain, Jesús and Prados Olleta, Nicolás and Campos Muñoz, Antonio Jesús and Alaminos Mingorance, Miguel and Garzón Bello, Ingrid Johanna},
}