@misc{10481/60188,
year = {2019},
url = {http://hdl.handle.net/10481/60188},
abstract = {Blood loss remains a major concern during surgery and can increase the morbidity of
the intervention. The use of topical haemostatic agents to overcome this issue therefore
becomes necessary. Fibrin sealants are promising haemostatic agents due to
their capacity to promote coagulation, but their effectiveness and applicability need
to be improved. We have compared the haemostatic efficacy of a novel nanostructured
fibrin‐agarose hydrogel patch, with (c‐NFAH) or without cells (a‐NFAH), against
two commercially available haemostatic agents in a rat model of hepatic resection.
Hepatic resections were performed by making short or long incisions (mild or severe
model, respectively), and haemostatic agents were applied to evaluate time to
haemostasis, presence of haematoma, post‐operative adhesions to adjacent tissues,
and inflammation factors. We found a significantly higher haemostatic success rate
(time to haemostasis) with a‐NFAH than with other commercial haemostatic agents.
Furthermore, other relevant outcomes investigated were also improved in the
a‐NFAH group, including no presence of haematoma, lower adhesions, and lower
grades of haemorrhage, inflammation, and necrosis in histological analysis. Overall,
these findings identify a‐NFAH as a promising haemostatic agent in liver resection
and likely in a range of surgical procedures.},
organization = {This work was supported by preclinical research
funds from the Regional Government of Andalusia through the
Andalusian Initiative for Advanced Therapies},
publisher = {Wiley},
keywords = {Bleeding},
keywords = {Fibrin agarose hydrogel},
keywords = {Fibrin sealant},
keywords = {Haemostatic agent},
keywords = {Liver resection},
keywords = {Nanostructured biomaterial},
title = {Nanostructured fibrin agarose hydrogel as a novel haemostatic agent},
doi = {10.1002/term.283110.1002/term.2831},
author = {Campos Cuerva, Rafael and Alaminos Mingorance, Miguel and Campos Muñoz, Antonio Jesús},
}