@misc{10481/60147,
year = {2019},
month = {6},
url = {http://hdl.handle.net/10481/60147},
abstract = {Angiopoietin-like protein 4 (ANGPTL-4) regulates lipidic metabolism and affects energy
homeostasis. However, its function in children with obesity remains unknown. We investigated
plasma ANGPTL-4 levels in children and its relationship with body mass index (BMI) and different
lipidic parameters such as free fatty acids (FFA). Plasma ANGPTL-4 levels were analyzed in two
different cohorts. In the first cohort (n = 150, age 3–17 years), which included children with normal
weight or obesity, we performed a cross-sectional study. In the second cohort, which included only
children with obesity (n = 20, age 5–18 years) followed up for two years after an intervention for
weight loss, in which we performed a longitudinal study measuring ANGPTL-4 before and after
BMI-loss. In the cross-sectional study, circulating ANGPTL-4 levels were lower in children with
obesity than in those with normal weight. Moreover, ANGPTL-4 presented a negative correlation with
BMI, waist circumference, weight, insulin, homeostasis model assessment of insulin resistance index
(HOMA index), triglycerides, and leptin, and a positive correlation with FFA and vitamin-D. In the longitudinal study, the percent change in plasma ANGPTL-4 was correlated with the percent change
in FFA, total-cholesterol and high-density lipoprotein cholesterol. This study reveals a significant
association of ANGPTL-4 with pediatric obesity and plasma lipid profile.},
organization = {This research was funded by INSTITUTO DE SALUD CARLOS III cofounded by FEDER, grants number
PI18/00998, PI15/01272, PI11/02042, PI16/01301, and PI16/00871, and FUNDACIÓN MUTUA MADRILEÑA},
publisher = {MDPI},
keywords = {ANGPTL-4},
keywords = {BMI loss},
keywords = {Childhood},
keywords = {Lipid profile},
keywords = {Obesity},
title = {ANGPTL-4 is Associated with Obesity and Lipid Profile in Children and Adolescents},
doi = {10.3390/nu11061340},
author = {Barja Fernández, Silvia and Aguilera García, Concepción María},
}