@misc{10481/60089,
year = {2011},
url = {http://hdl.handle.net/10481/60089},
abstract = {The buccal tablets were formulated using the rate controlling polymers such as carbopol 974 P and Hydroxy propyl methyl cellulose K4M (HPMC K4M) or Sodium alginate in various ratios by D-Optimal design. Numerical optimization technique was applied to find out the best formulation by using the software Design Expert. All the formulations were evaluated and it was found that the carbopol 974P have good bioadhesion property but the HPMC K4M controls the drug release. In vitro drug release and release exponent were considered as dependent variables for optimization. The ideal formulation was undergone in vitro diffusion studies and stability studies.},
abstract = {Para la formulación de los comprimidos orales se usó la tasa de control de polímeros tales como carbopol 974P e hidroxipropilmetilcelulosa K4M (HPMC K4M) o alginato de sodio en varias proporciones, mediante el método de diseño D-Optimal. Se utilizó el programa Design Expert para aplicar la técnica de optimización numérica y encontrar la formulación óptima.  Después de evaluar todas las formulaciones, se encontró que el carbopol 974P tiene propiedades de bioadhesión buenas pero el HPMC K4M controla la liberación del fármaco. In vitro, la liberación del fármaco y el exponente de liberación se consideraron variables dependientes para la optimización. La formulación ideal se realizó mediante estudios de difusión y de estabilidad in vitro.},
publisher = {Universidad de Granada, Facultad de Farmacia},
keywords = {Bucal tablet},
keywords = {Diclofenac sodium},
keywords = {D-Optical design},
keywords = {Optimization},
keywords = {Comprimido oral},
keywords = {Diclofenaco sódico},
keywords = {Diseño D-Optimal},
keywords = {Optimización},
title = {Design, development and optimization of buccal bioadhesive tablets of diclofenac sodium for the treatment of odontalgia},
author = {Edavalath, S. and Prakash Rao, B.},
}