@misc{10481/59942,
year = {2019},
url = {http://hdl.handle.net/10481/59942},
abstract = {In breast cancer (BC), the presence of cancer stem cells (CSCs) has been
related to relapse, metastasis, and radioresistance. Radiotherapy (RT) is an
extended BC treatment, but is not always effective. CSCs have several
mechanisms of radioresistance in place, and some miRNAs are involved in
the cellular response to ionizing radiation (IR). Here, we studied how IR
affects the expression of miRNAs related to stemness in different molecular
BC subtypes. Exposition of BC cells to radiation doses of 2, 4, or 6 Gy
affected their phenotype, functional characteristics, pluripotency gene
expression, and in vivo tumorigenic capacity. This held true for various
molecular subtypes of BC cells (classified by ER, PR and HER-2 status),
and for BC cells either plated in monolayer, or being in suspension as
mammospheres. However, the effect of IR on the expression of eight stemness-
and radioresistance-related miRNAs (miR-210, miR-10b, miR-182,
miR-142, miR-221, miR-21, miR-93, miR-15b) varied, depending on cell
line subpopulation and clinicopathological features of BC patients. Therefore,
clinicopathological features and, potentially also, chemotherapy regimen
should be both taken into consideration, for determining a potential
miRNA signature by liquid biopsy in BC patients treated with RT. Personalized
and precision RT dosage regimes could improve the prognosis, treatment,
and survival of BC patients.},
organization = {This work has been partially funded by the Consejería
de Economía, Conocimiento, Empresas y Universidad
de la Junta de Andalucía and European Regional
Development Fund (ERDF), ref. SOMM17/6109/
UGR, and with grants from the Ministry of Economy
and Competitiveness (FEDER funds, projects no.
PIE16/00045) and from the Chair ‘Doctors Galera-
Requena in cancer stem cell research’ (CMC-CTS963).},
publisher = {FEBS Press},
keywords = {Biomarkers},
keywords = {Breast cancer},
keywords = {miRNAs},
keywords = {Radiotherapy},
keywords = {Radiation},
title = {miRNAs as radio-response biomarkers for breast cancer stem cells},
doi = {10.1002/1878-0261.12635},
author = {Griñán Lisón, Carmen and Olivares Urbano, María Auxiliadora and Jiménez, Gema and López Ruiz, Elena and Val Muñoz, María Coral Del and Morata-Tarifa, Cynthia and Entrena, José Manuel and González Ramírez, Amanda Rocío and Boulaiz Tassi, Houria and Zurita Herrera, Mercedes and Núñez Torres, María Isabel and Marchal Corrales, Juan Antonio},
}